Rat Heart Mitochondrial Cardiolipin Oxidation During Ischemia in ：大鼠心肌线粒体心磷脂氧化过程中缺血.ppt

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2018-06-24 发布于浙江
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Rat Heart Mitochondrial Cardiolipin Oxidation During Ischemia in ：大鼠心肌线粒体心磷脂氧化过程中缺血.ppt

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Rat Heart Mitochondrial Cardiolipin Oxidation During Ischemia in ：大鼠心肌线粒体心磷脂氧化过程中缺血

Heart Mitochondrial Cardiolipin Oxidation during Ischemia in the Aged Rat E. Lesnefsky, P. Minkler, Charles Hoppel Case School of Medicine Louis Stokes VA Medical Center Heart Mitochondrial Cardiolipin Oxidation during Ischemia in the Aged Rat Introduction Mitochondria in aging heart Mitochondrial Cardiolipin – ischemia in aging heart Summary Increased Injury in Aging Heart Aging hearts showed increased injury: Decreased hemodynamic recovery Increased CPK release-increased tissue damage Aging myocardium has an increased intrinsic susceptibility to damage during ischemia and reperfusion Heart Mitochondrial Cardiolipin Oxidation during Ischemia in the Aged Rat Introduction Mitochondria in aging heart Mitochondrial Cardiolipin – ischemia in aging heart Summary Heart Mitochondrial Cardiolipin Oxidation during Ischemia in the Aged Rat Problem Mitochondria in aging heart Mitochondrial Cardiolipin – ischemia in aging heart Summary Content of Cardiolipin is Unaltered by Ischemia and Reperfusion in Adult and Aged Hearts OD 206 peak area ratio = 1496 peak /1448 peak Peaks identified by subsequent MS Heart Mitochondrial Cardiolipin Oxidation during Ischemia in the Aged Rat Problem Mitochondria in aging heart Mitochondrial Cardiolipin – ischemia in aging heart Summary Conclusions Oxidative damage to cardiolipin occurs in the ischemic-reperfused aged, but not the adult heart. Ischemia alone is sufficient to induce oxidative damage to cardiolipin in the aged rat heart. Cardiolipin modification provides evidence of enhanced oxidative damage to mitochondria during ischemia in the aged heart. * Edward Lesnefsky, M.D. Paul Minkler Shadi Moghaddas, Ph.D. Bernard Tandler, Ph.D. Qun Chen, M.D., Ph.D. Medhat Hassan, M.D. Edwin Vazquez Alessandro Riva, M.D., Ph.D. Funding: NIA PO1 AG15885 Aging Heart: Basis of Increased Ischemic/Reflow Injury Cardiac Mitochondria Exist in Two Populations: Subsarcolemmal Mitochondria (SSM) and Interfibrillar Mitochondria (I