TRACO - Center for Cancer Research：该给癌症研究中心.ppt

* * The BB2R regulates EGFR tyrosine phosphoryation leading to increased cancer cell proliferation, survival and metastasis SUMMARY SCLC is a neuroendocrine tumor which initially responds to chemotherapy but subsequently relapse occurs. Multiple clinical trials are in progress to improve the treatment of SCLC patients. Smoking cessation. First line treatments approved by FDA. Nicotine replacement therapy (NRT) includes gum (Nicorette), patch (Nicoderm CQ) or nasal spray (Nicotrol) Pills. Bupropion is an antidepressant or Varenicline tartrate (Chantix) reduces smoking urge and withdrawal symptoms Smoking cessation Smoking cessation can be achieved with or without assistance from healthcare professions or the use of medication. Early “failure” is a normal part of trying to stop smoking. Smoking cigarettes leads to nicotine addiction. Most smokers quit cold turkey after a gradual cigarette reduction Health benefits of cigarette cessation Within 20 min after quitting, blood pressure and heart rate decrease to normal levels Within 12 hours, carbon monoxide levels in blood return to normal Within 2 days the sense of smell and taste return Within 9 months there is a decrease in cough and shortness of breath Within 10 years, the risk of stoke is normal and the risk of dying from lung cancer is reduced by 50% Smoking cessation. There are now 45 million ex-smokers at high risk of getting lung cancer. There remain 45 million smokers in the U.S., but only 16% will die from lung cancer. 1-800-QUITNOW References: Y. Sekido, K.M. Fong and J.D. Minna. Cancer of the Lung, In “Cancer: Principles and practice of Oncology.” Edited by V.T. DeVita, S. Hellman and S.A. Rosenberg, Lippincott, Williams Wilkins, 745-752 (2006). L.C. Cantley, C.L. Carpenter, W.C. Hahn, M. Meyerson. Cell signaling, growth factors and their receptors, In “Cancer: Principles and practice of Oncology.” Edited by V.T. DeVita, T.S. Lawrence and S.A. Rosenberg, Lippincott, Williams Wilkins, 75-67 (201