TRACO - Center for Cancer Research_86123：该给癌症research_86123中心.ppt

* * Despite the name there are several patterns of disease which are characterized by chronicity ot smoldering The combination of the facts that the disease is largely clonal or oligoclonal and there is a long latency between infection and development of illness suggests that the events leading to disease are slow and may involve an additional transforming event Recently gastric lympoma was identified with HTLV-I integrated so these designations may undergo change can be primary gastric NHL with HTLV-I integration Eur J Gastroenterol Hepatol 2000 Mar;12(3):357-60 * * AIDS Res Hum Retroviruses. 2004 May;20(5):465-75. Thailand The CRF strains identified were CRF02_AG-like, CRF01_AE-like, and CRF11_cpx. Two new intersubtype recombinant infections, H/G and A/F2, were identified. Zolla-Pazner Cameroon The subtype distribution was subtype B 59%, C 18%, A 8%, CRF02_AG 5%, CRF01_AE 4%, D 3% and G 2%. Denmark Scand J Infect Dis. 2003;35(11-12):800-7. Two percent of HIV-positive U.S. blood donors are infected with non-subtype B strains. AIDS Res Hum Retroviruses. 2003 Dec;19(12):1065-70. Military 5% * * * * * * * * * * * The only vorus group that has a single promoer with som many gene products * The only vorus group that has a single promoer with som many gene products * HIV Replication.Integration Integration Bushman , TIG Hazuda 2005 HIV ReplicationTranslation, Assembly, Maturation Translation Maturation Assembly Translation of HIV gag/pol and env Paradigm: Process Polyprotein Precursors env pol gag Gp120 Gp41 HIV Particle MaturationImmature particle and mature particle HIV Particle Maturation HIV Protease HIV advertisement HIV ReplicationTranslation, Assembly, Maturation Translation Maturation Assembly Retroviruses Retroviruses in Human Populations Lentivirus RelationshipsHIV-2 is closely related to SIV-smm, whereas SIV-syk is distantly relatedHIV-1 and SIV-cpz are closely related whereas SIV agm and SIV-mnd are distantly relate