Virus Host co-evolution in sight of their proteomes and codon 在他们的蛋白质、病毒与宿主的协同进化的密码子的视线.pptVIP

Virus Host co-evolution in sight of their proteomes and codon preferences Bioinformatics project 2007 Yaar Reuveni Instructor - Michal Linial Outline: My project is composed of two phases: Phase I: The virus host web tool – VirOsNet. You are welcome to visit at: www.virosnet.cs.huji.ac.il Phase II: Virus Host co-evolution research using codon usage analysis. Viruses: Few facts: Effective virus is a one that ‘found the key’ to enter the cell Mice lack receptors for polio viruses. Mice are resistant to polio virus ‘efficient replication within the cell’ Fever can help to inhibit virus replication ‘crossing the main door’ Crossing the epithelial mocus. I.e paramyxovirus enters by binding sialic acid receptors. Some host glycoproteins can compete with the cell receptors and block infection. Viruses fight back: Phase I: VirOsNet VirOsNet provides database and tools for exploring virus evolution and virus-host co-evolution Background and Motivation: Ample of examples suggest that often viruses steal information from their hosts. Viruses must optimize their amount of genetic material and physical size. Viruses have very fast evolution: Hard to trace. Might change by switching hosts. Shuffle their genetic material. Phase (I) main objective: Compare all viral proteins to all known proteins and detect resemblance. Meaning: in what way do viral proteins resemble any of all other known proteins in our world? Objectives and possible outcomes (i) Clever search: Provide crossbreeding factors when searching Offer comparisons of viruses relative to the proteome of their known hosts Stolen elements: where were they stolen from? Was it from the host? Mimicking phenomenon: detect host - protein mimicry When did it happen: Evolutionary tracking Objectives and possible outcomes (ii) Recent event – indicative by similarity search results that are exceptional. Insights on viruses and their proteomes. Long term: Pharmaceutics applications. Proposal