Systematic Review on the effects of asthma medication …：对哮喘药物疗效的系统评价….ppt

Neste tambem, referencia para o “Clinic Source Methods” * Comprehensive, exhaustive search of articles in databases such as PubMed, SCOPUS and ISI Web of Knowledge: * * * * * * * * * * SYSTEMATIC REVIEW ON THE EFFECTS OF ANTI-INFLAMMATORY ASTHMA MEDICATION ON FENO VALUES Class 19 FMUP 2008/2009 Adviser: Dr. Jo?o Fonseca INDEX Statement of the Problem Background Main Problem Aims Methods Expected Results References Asthma is a disease with high prevalence and morbidity 1; There are different types of Asthma Medication, some have anti-inflammatory effects; FENO is a biomarker of airways’ inflammation. What are the effect of anti-inflammatory asthma medication on FENO values? STATEMENT OF THE PROBLEM 1 GLOBAL INITIATIVE FOR ASTHMA BACKGROUND WHAT IS ASTHMA? Asthma is a chronic inflammatory disorder of the airways.1 1 GLOBAL INITIATIVE FOR ASTHMA 2006 BACKGROUND ASTHMA MEDICATION2: Anti-inflammatory Agent Drugs Leukotriene Antagonists Montelukast Zafirlukast Zileuton Inhaled Glucocorticoids Fluticasone Budesonide Triamcinolone Flunisolide Beclomethasone Mometasone Oral Glucocorticoids Prednisone Methylprednisolone Hydrocortisone 2 National Heart, Lung, and Blood Institute; National Asthma Education and Prevention Program BACKGROUND WHAT IS NITRIC OXIDE? - It’s a gas produced by cells that line the inner wall of the airways; - The amount of nitric oxide exhaled shows how much inflammation there is in the lungs. 3 3 JONGSTE J.C. 2005 MAIN PROBLEM Normal values of FENO aren’t clearly defined; FENO values are influenced by demographic and biological factors; Some effects of anti-asthma medication on FENO values have been reported. AIMS Evaluate the effect of anti-inflammatory asthma medication and its magnitude on FENO values, namely: ? Leukotriene modifiers; Inhaled Corticosteroids; Oral Corticosteroids; METHODS STUDY DESIGN: SYSTEMATIC R