Scalable architecture in mammalian brains在哺乳动物的大脑可扩展的体系结构.ppt

Too many learning rules! Plasticity at CA3-CA1: a separable process? Questions at the CA3-CA1 synapse Is timing between single spikes sufficient to describe the actual learning rule? How different are the requirements for potentiation and depression? Are these full inverses of each other? How might the learning rule map to behavior? Can cell biology help clarify these issues conceptually? At CA3-CA1 synapses, pairing of single spikes fails to induce potentiation However… Observations on the LTP learning rule Potentiation requires postsynaptic bursts Pairings are effective at 5 Hz (near theta) …does depression have these requirements? LTD occurs under many timing conditions Conclusions so far Potentiation and depression have different general induction requirements. Potentiation: active exploration (causal, bursts, 5 Hz) Depression: many conditions During theta, the rule acts like a phase detector. At other times, the rule is depression-only. Subthreshold and spiking behavior for “natural” stimulation ensembles Local amplification in dendritic branches Strategies for separating LTD and LTP LTD and LTP are separable LTD is fully reversible LTP is not fully reversible! After being induced, LTP becomes locked in The starting distribution of CA3-CA1 synapses The CA3-CA1 learning rule * Functional dissection of the CA3-CA1 learning rule Sam Wang Princeton University /~sam/Wang-STDP.ppt Optical physiology and synaptic plasticity: Shari Gelber Daniel O’Connor Dmitry Sarkisov Shy Shoham Megan Sullivan Gayle Wittenberg Brain scaling and evolution: Mark Burish Damon Clark Kim Hatch Harrison Hao Yuan Kueh Jennifer Shultz Matt Wagers Krysta Wyatt Laboratory of Sam Wang Abbott and Nelson, Nat. Neurosci. CA3-CA1 synapse of hippocampus Rich history of extracellular and single-cell recording The cell biology and plasticity literature is vast One synapse per connection Has AMPA, NMDA, mGlu