针灸改善高血压患者 内皮血管收缩功能失调.pptVIP

This report is about the Telmisartan, a kind of angiotensin II type 1 receptor blockers (ARBs), which not only decreased blood pressure but also improved endothelial function in patients with hypertension. * Endothelial function can be assessed clinically by measuring brachial artery flow-mediated vasodilation (FMD). Arterial occlusion is created by cuff inflation to at least 50 millimeters of mercury (mm Hg) above systolic pressure to occlude arterial inflow. Subsequent cuff deflation induces a brief high-flow state through the brachial artery, so the vessel is dilated. FMD is calculated as the percent change in diameter 1 minute after the cuff release compared to the baseline diameter before the cuff release. In this figure, you can see the vessel dilated after the cuff release. * Now, I’d like to explain Nitric Oxide briefly. Nitric Oxide is what is produced from endothelium by eNOS,. NO from the endothelium plays an important role in protecting endothelium against the onset and progression of atherosclerosis which is associated with endothelial dysfunction. The anti-atherosclerotic roles of NO include regulation of blood pressure and vascular tone, inhibition of platelet aggregation and leukocyte adhesion, and prevention of smooth muscle cell proliferation. Thus, reduced concentration or bioavailability of NO is thought to be one of the central factors common to atherosclerotic disease. * Let’s move on to the question of the Acupuncture Hypertension There have been many reports demonstrating that acupuncture can lower blood pressure in hypertensive patients, Recently, two well-controlled, randomized, blinded studies also reported that acupuncture gave significant benefits to hypertensive patients. However, little is known about whether acupuncture could improve endothelial dysfunction. * Although there have been no studies about that acupuncture could improve endothelial dysfunction, several studies have shown that acupuncture enhances the gene