免疫物学课件十二.pptVIP

Transplantation Immunology 中国科学院上海生命科学研究院/上海交通大学医学院 健康科学研究所 上海市免疫学研究所 张雁云 Contents Transplantation Types of transplantation Normal Glomerulus 肾移植物中的急性排斥反应 Immunoflourescence of Abs HE Anti-CD3 Peroxides Stain of T cells in Myocardium 心脏移植物中的急性排斥反应 Chronic rejection Months to years after transplantation Slow, progressive loss of function Proliferation of fibroblasts and vascular cells Probably due to cytokines secreted by alloreactive T cells Chronic allograft dysfunction, CAD Section II HVGR renal artery interstitial fibrosischronic inflammation 肾移植物中的慢性排斥反应 Factors in Chronic Rejection Section II HVGR Summary Section II HVGR Types of rejection Graft versus Host Reaction GVHR 特定条件 受者与供者之间MHC不合 移植物含有足够数量的免疫细胞 受者处于免疫无能或免疫功能严重缺陷状态 Section II GVHR Overview of GVHD Section II GVHR GVLR 骨髓移植物中的供者免疫细胞向残留的白血病细胞发动攻击， 从而防止白血病复发。 Section II GVHR Section II GVHR DLI诱导GVLR的机制： 受者体内出现特异性识别白血病细胞的供者T细胞克隆 DLI诱导调节性T细胞，抑制GVHD发生 激活的供者淋巴细胞产生某些细胞因子， 诱导白血病细胞高表达Fas抗原 Section I: Allogeneic transplantation rejection 1 Section II: Types of rejection 2 Section III: Prevention and treatment 3 Section IV: Relative immunity 4 公元4世纪 罗马教堂 Long long ago… I: cellular tissue transplantation organ II: autologous syngeneic allogeneic xenogeneic transplantation Transplantation 1956 first successful bone marrow transplantation1969 relatives  1977 unrelated Milestone 1956 Transplant immunity “laws” of transplantation: Autogeneic grafts survive Syngeneic grafts survive Allogeneic grafts are rejected Parent-to-F1 grafts survive F1-to-parent grafts are rejected Xenogeneic grafts are rejected In an allogeneic graft, donor and recipient c