wif-1 dkk3和sfrps基因甲基化状态及mrna表达与食管鳞癌关系研究-relationship between methylation status and mrna expression of wif - 1 dk k3 and sf rps genes and esophageal squamous cell carcinoma.docxVIP

tissues 43.3% (13/30) (p0.05). sfrp2 gene was methylated in 45 of 65 (69.2%) tumor specimens, which was significantly higher than that in corresponding normal tissues 36.7% (11/30) (p0.05). sfrp4 gene was methylated in 43 of 65 (66.2%) tumor specimens, which was significantly higher than that in corresponding normal tissues 6.7% (2/30) (p0.05). sfrp5 gene was methylated in 37 of 65 (57.0%) tumor specimens, which was significantly higher than that in corresponding normal tissues 6.7% (2/30) (p0.05). The methylation status of wif-1, dkk3, sfrp1, sfrp2 and sfrp5 gene have no relationship with cli