治疗研究评析.pptVIP

业精于勤荒于嬉 行成于思毁于随 →【医学生物PPT，欢迎收藏分享】豆丁网友 Critical Appraisal of Therapy Study“治療研究”的評析 Are the results of the trial valid (效度如何)？ Was the assignment of patients to treatment randomised (是隨機分配嗎)？ Were the groups similar at the start of the trial (試驗開始時兩組條件是否相似)？ Aside from the allocated treatment, were groups treated equally (兩組其他治療條件一樣)？ Were all patients who entered the trial accounted for and were they analysed in the groups to which they were randomised (所有進入試驗者皆列入統計，並依所分配的組別計算)？ Were measures objective or were the patients and clinicians were blinded (結果的測量客觀，受試者及醫師都不知道所接受的治療為何)？ What were the results (結果為何)？ How large was the treatment effect (治療效果有多大)？ How precise was the estimate of the treatment effect (治療效果的預測多準確)？ Will the results help me in my patient care (適用於我的病人嗎)？ Was the assignment of patients to treatment randomised是隨機分配嗎？ Were the groups similar at the start of the trial試驗開始時兩組條件是否相似？ Aside from the allocated treatment, were groups treated equally 兩組其他治療條件一樣？ Were all patients who entered the trial accounted for and were they analysed in the groups to which they were randomised所有進入試驗者皆列入統計，並依所分配的組別計算？ Were measures objective or were the patients and clinicians were blinded結果的測量客觀，受試者及醫師都不知道所接受的治療為何？ How large was the treatment effect 治療效果有多大？ How precise was the estimate of the treatment effect 治療效果的預測多準確？ The true risk of the outcome in the population is not known The best we can do is to estimate the true risk based on the sample of patients in the trial We can gauge how close this estimate is to the true value by looking at the confidence intervals (CI) Narrow CI represents a precise reflection of the population value The CI also provides us with information about the statistical significance of the result If the value corresponding to no effect falls outside the 95% CI then the result is statistically significant at the 0.05 level If the CI includes the value corresponding to no effect then the results are not statistically significan