吡格列酮减轻糖尿病大鼠肾脏损伤及其对肾组织podocalyxin表达的影响-pioglitazone alleviates renal injury in diabetic rats and its effect on the expression of podophylloxin in renal tissue.docx

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吡格列酮减轻糖尿病大鼠肾脏损伤及其对肾组织podocalyxin表达的影响-pioglitazone alleviates renal injury in diabetic rats and its effect on the expression of podophylloxin in renal tissue.docx

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吡格列酮减轻糖尿病大鼠肾脏损伤及其对肾组织podocalyxin表达的影响-pioglitazone alleviates renal injury in diabetic rats and its effect on the expression of podophylloxin in renal tissue

3.4吡格列酮对糖尿病大鼠尿PCX排泄及肾组织中PCX表达的影响373.4.1各组大鼠尿PCX排泄动态变化373.4.2肾组织PCX蛋白表达383.4.3肾皮质PCXmRNA表达393.5UPCR分别与UACR和KI的相关性分析404讨论·························································································414.1糖尿病肾脏疾病发病机制概述······················································414.2糖尿病肾脏疾病和足细胞损伤······················································414.3吡格列酮对糖尿病大鼠肾组织的保护作用·······································424.4吡格列酮对糖尿病大鼠尿PCX排泄及肾组织PCX表达的影响434.4.1PCX的功能434.4.2吡格列酮对尿PCX排泄的影响444.4.3吡格列酮对肾组织PCX蛋白及mRNA表达的影响444.5吡格列酮保护足细胞的作用机制···················································464.6实验中的经验和不足··································································495结论·························································································50参考文献······················································································51附录个人简历···············································································63致谢····························································································65综述····························································································66中英文缩写对照表缩写AGEs英文名称advancedglycosylationendproducts中文名称终末糖基化产物Albalbumin白蛋白AngIIangiotensinII血管紧张素IIAODaverageopticaldensity平均光密度AT1angiotensinIItype1receptor血管紧张素II1型受体BMbodymass体重BSAbovineserumalbumin牛血清白蛋白BUNbloodureanitrogen尿素氮DEPCdiethylpyrocarbonate焦碳酸二乙酯DMdiabetesmellitus糖尿病DNdiabeticnephropathy糖尿病肾脏疾病ECMextracellularmatrix细胞外基质ELISAenzyme-linkedimmunosorbentassay酶联免疫吸附法FBGfastingbloodglucose空腹血糖FPfootprocess足突FPFRfootprocessfusionrate足突融合率GAPDHglyceraldehydephosphatedehydrogenase磷酸甘油醛脱氢酶GBMglomerularbasementmembrane肾小球基底膜GBMTglomerularbasementmembranethickness基底膜厚度HbA1cglycosylatedhemoglobinA1c糖化血红蛋白A1cHDL-Chigh-densitylipoproteincholesterol高密度脂蛋白胆固醇HEhematoxylin-eosin苏木精-伊红IODintegratedopticaldensity累计光密度KIkidneyhypertrophyindex肾脏肥大指数LDL-Clow-densitylipoproteincholesterol低密度脂蛋白胆固醇MGAmeanglomerularcross-sectionalarea平均肾小球截面积MGVmeanglomerularvolume平均肾小球体