不同硬度聚丙烯酰胺凝胶基底对内皮细胞生物力学行为影响-effect of polyacrylamide gel substrates with different hardness on biomechanical behavior of endothelial cells.docxVIP

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2018-06-28 发布于上海
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不同硬度聚丙烯酰胺凝胶基底对内皮细胞生物力学行为影响-effect of polyacrylamide gel substrates with different hardness on biomechanical behavior of endothelial cells.docx

不同硬度聚丙烯酰胺凝胶基底对内皮细胞生物力学行为影响-effect of polyacrylamide gel substrates with different hardness on biomechanical behavior of endothelial cells

ABSTRACTCardiovasculardisease(CVD)isakindofdiseasewithhighdeathrateandmorbidityaroundtheworld,Atherosclerosis(AS)isthemaindisease.DuringtheprocessofAS,sincethevascularsmoothmuscleCells(VSMCs)migrationandproliferation,overproductionofabnormalcollagenaswellasdiminishedquantitiesofnormalelastin,complianceofthevascularwallmaybedecreased,thevesselbecomesstiffening.Evidenceisnowemergingthatchangesinvesselstiffnesscanincreaseendotheliumpermeabilityandleukocytetransmigration,bothofwhicharehallmarksofatherosclerosisprogression.Now,majorstudyaboutASfocusonSMCsandinflammation,investigationonmatrixrigidit

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不同硬度聚丙烯酰胺凝胶基底对内皮细胞生物力学行为影响-effect of polyacrylamide gel substrates with different hardness on biomechanical behavior of endothelial cells.docxVIP