不对称催化合成手性3,3′-氮环螺环氧化吲哚-asymmetric catalytic synthesis of chiral 3,3 ′ - azacyclospiro epoxidized indole.docx

attracted considerable attention as it hold great potential in the creation of new transformations, which each type of catalysts failed to afford alone. The strategy also provides a powerful tool for saving both energy and resources. In this manuscript, we have presented a highly enantioselective synthesis of spiro[4H-pyrilindin-3,3-oxindole] derivatives via Mannich reaction of 3-substituted oxindoles and N-Boc-imines followed by intramolecular hydroamination catalyzed by a gold(I) complex with the assistance of a Br?nsted acid additive in one pot. Through systemic study, we found that the c