-丹酚酸A和丹酚酸B改善大鼠心肌缺血作用比较.docVIP

PAGE \* MERGEFORMAT 1 丹酚酸A与丹酚酸B改善大鼠心肌缺血作用比较 作者：宋延平,孔令姗,吴静,苗爱蓉,赵刚 【摘要】 目的 观察丹酚酸A与丹酚酸B对大鼠心肌缺血的作用。方法 通过结扎大鼠冠脉以及静脉注射脑垂体后叶素两种方法,观察舌下注射丹酚酸A 10、5、2.5 mg/kg及丹酚酸B 10 mg/kg对大鼠不同时间点心电图、血清肌酸激酶(CK)、乳酸脱氢酶(LDH)及心肌梗死面积的影响。结果 丹酚酸A 10、5、2.5 mg/kg及丹酚酸B 10 mg/kg对结扎大鼠冠脉导致的急性心肌梗死模型有降低心电图ST段抬高程度、减少梗死面积及降低血清CPK、LDH的作用,其中丹酚酸A 10、5 mg/kg的效价明显高于丹酚酸B,2.5 mg/kg丹酚酸A的作用相当于10 mg/kg丹酚酸B；对静脉注射脑垂体后叶素导致的大鼠急性心肌梗死模型有降低心电图ST段抬高程度作用,其中丹酚酸A 10、5 mg/kg的作用明显强于丹酚酸B,2.5 mg/kg丹酚酸A的作用与10 mg/kg丹酚酸B无显著差异。结论 10、5 mg/kg丹酚酸A改善大鼠心肌缺血作用明显强于10 mg/kg丹酚酸B,2.5 mg/kg丹酚酸A改善大鼠心肌缺血作用相当于10 mg/kg丹酚酸B。 【关键词】 丹酚酸A；丹酚酸B；大鼠；心肌缺血 Abstract：Objective To investigate the effects of salvianolic Acid A and B (Sal A, Sal B) on acute myocardial ischemia of rats. Method The rat model with acute myocardial ischemia was established by coronary ligation and intravenous injection of posterior pituitary. The effect of Sal A 10, 5, 2.5 mg/kg and Sal B 10 mg/kg on the electrocardiogram of different time points, serum creatine kinase (CK), lactate dehydrogenase (LDH) and myocardial infarction area were observed. Results To the rat model was established by coronary ligation, Sal A 10, 5, 2.5 mg/kg and Sal B 10 mg/kg could lower the ST-segment elevation, reduce infarct size and serum CPK, LDH. The effect of Sal A 10, 5 mg/kg was significantly higher than that of Sal B. The role of Sal A 2.5 mg/kg was equivalent to Sal B 10 mg/kg. To the rat model was established by intravenous injection of posterior pituitary, Sal A 10, 5, 2.5 mg/kg and Sal B 10 mg/kg could lower the ST-segment elevation. The effect of Sal A 10, 5 mg/kg was significantly higher than that of Sal B. The role of Sal A 2.5 mg/kg and sal B 10 mg/kg had no significant difference. Conclusion Treatment with Sal A 10, 5 mg/kg was more effective in the rat models with acute myocardial ischemia than Sal B 10 mg/kg. Sal A 2.5 mg/kg improved acute myocardial ischemia in rats was equivalent to Sal B 10 mg/kg. 　　Key words：salvianolic acid A；salvianolic acid B；myocardial ischemia；rat 　　丹参是常用的活血