呼吸系统疾病(三) DISEASES OF RESPIRATORY SYSTEM ….pptVIP

Cigarette smoking is the main cause of lung carcinoma Heavy cigarette smokers have a 20-fold increases in incidence compared with nonsmokers Cessation of smoking decrease the risk A large number of potent carcinogens are present in cigarette smoke Including polycyclic hydrocarbons, aromatic amines, and heavy metals such as nickel Produce changes in the respiratory: Loss of cilia—squmous metaplasia, dysplasia ,carcinoma in situ, Dysplasia is very uncommon in nonsmokers, Dysplasia ,carcinoma in situ * Industrial carcinogens * * Large cells show no squamous or glandular differentiation. Pleomorphic giant cell, multinucleated giant cells * * Pneumonia Chronic Obstructive Passive Diseases Silicosis NPC and Lung cancer Summary * Air space pneumonia Lobar pneumonia Lobular pneumonia Interstitial pneumonia Viral pneumonia Mycoplasma pneumonia * COPD Silicosis COPD: Chronic bronchitis Asthma Emphysema Bronchiectasis Silicosis Asbestosis Pulmonary hypertension Chronic cor pulmonale * NPC Lung carcinoma NPC EBV infection Nasopharygeal roof Non-keratinizing squamous carcinoma Lymphatic route metastasis Lung carcinoma Smoking Hilar, periphera, diffuse type Squamous carcinoma and small cell carcinoma Haematogenous spread * Case abstract 1 Male, 70, he had suffered from cough and sputum for 15 years, rapid and short breath after physical labor for 5 years, lower limbs edema repeatedly for 1 year. These symptoms aggravated 4 days ago with fever and purulent sputum. * Blood WBC: 10.2 X 109/L X-ray: The lungs are enlarged, Several scattered patchy shadows evidently in bilateral lower lobes. Biopsy: Thinning and destruction of alveolar walls, large airspaces formation. Terminal bronchiole and alveoli are filled with neutrophil. * Chronic bronchitisEmphysema Chronic Cor pulmonale Lobular pneumonia COMPLICATED WITH * 65, woman, cough with purulent sputum after catching cold 15 years ago. She develope