浅谈广州地区组链球菌t分型的分布状况.docVIP

使用前删除此我爱浪漫樱花文档主页： HYPERLINK /mtl168168 /mtl168168，分享文档快乐生活快乐无阻PAGE PAGE 2 浅谈　　【摘要】目的　研究广州地区风湿热易感自然人群a组链球菌（gas）t型的分布状况。方法从1990年5月至1991年4月，对广州地区9～14岁学龄儿童共453名（城市250名，农村203名）每月取咽拭子培养1次，分离β-溶血性链球菌后，采用兰菲分组鉴定出gas共732株，对gas采用凝集法进行t分型。结果　广州市学龄儿童携带的gas的t型以t6(20.5%)、t4(12.0%)、t12(10.9%)多见。t型分布无性别差异(p＞0.05)，但有季节差异。同一学校不同班级有不同的 t型分布。不可分型菌株占13.3%。结论　1990～1991年广州地区学龄儿童流行gas的t型主要以t6、4、12为多见；不同时期和不同地区流行gas的t型分布存在差异。 　　epidemic trends of t-typing of group a streptococci in guangzhou area ? 　　 【abstract】objective　to investigate the epidemic trends of the t typing of group a hemolytic streptococci (gas) isolated from guangzhou school children in china from 1990 to 1991.methods　732 group a streptococci were isolated from throat culture of 453 school children aged 9～14 years in guangzhou city, south china from may 1990 to april 1991. their t-type detection rates, t-type epidemics, monthly isolation rates, and isolation rates by sex were analysed epidemiologically.results　among the children, the most common serotype was t6 (20.5%),followed by t4(12.0%), and t12 (10.9%). the main serotype in guangzhou urban areas was t6 (30.6%), and in the rural areas was? ;t12 (21.0%). there was statistically significant difference (p＜0.005) between urban and rural areas. there was no significant difference between male and female, but quite difference in different seasons. different class in the same school had different t serotype distribution. non-typable strains reached 13.3%.conclusion　the dominant prevalent strains of gas were t6, 4, 12 in guangzhou school children， south china from 1990 to 1991. the distribution of gas t-typing varied from different regions and periods. 　　 【key words】streptococci pyogenes;bacterial typing techniques;rheymatic fever 　　研究证实，风湿热 (rf)的发生仅与 a组溶血性链球菌（gas）上呼吸道感染有关，因而对gas分型的分布状况研究显得非常重要。国外对风湿热易感自然人群（5～18岁）中携带gas血清学分型已进行了大量的研究，对风湿热的流行病学、预防和控制以及对gas疫苗的研制均具有重要的意义。在我国，对此方面的研究较少。由于m蛋白容易丢失，其抗血清难以制备，通过对gas菌株的 t型推断 m型的流行分布趋势，使 t型变得更加重要。我们分析了广州地区 rf易感人群携带gas者菌株的 t型的分布，拟推测相应的