冠心病患者胰岛素抵抗与炎症因子关系及意义研究.docVIP

冠心病患者胰岛素抵抗与炎症因子关系及意义研究 　　[摘要] 目的 研究冠心病患者胰岛素抵抗与炎症因子的关系。 方法 选取本院心内科120例患者为研究对象，根据患者的冠状动脉造影及糖耐量情况进行分组：对照组40例（冠心动脉和糖耐量均正常者）、观察Ⅰ组（单纯冠心病）40例、观察Ⅱ组（冠心病并发糖耐量异常）40例。检测当天采集空腹静脉血5 ml，采用全自动生化分析仪对血液样本的FBG、2 h BG、血脂等项目进行检测；采用酶联免疫法测定胰岛素含量，根据公式计算胰岛素抵抗指数（IRI）；采用散射光比浊法测定C反应蛋白（CRP）含量；冠状动脉造影检测，根据直径法分别对患者左、右冠状动脉狭窄程度进行评价。 结果 对照组和观察Ⅰ组患者的FBG、CRP、肿瘤坏死因子差异无统计学意义；观察Ⅰ组患者的空腹胰岛素、肿瘤坏死因子高于对照组，观察Ⅱ组患者的IRI、CRP、肿瘤坏死因子水平均比观察Ⅰ组高，IRI、CRP、肿瘤坏死因子水平由对照组、观察Ⅰ组、观察Ⅱ组呈显逐渐升高的趋势。 结论 对于冠心病患者要适当改善胰岛素抵抗作用，减轻患者的炎性症状反应，从而起到保护血管内皮的作用，对于冠心病合并糖尿病患者有重要的临床意义。 　　[关键词] 冠心病；胰岛素抵抗；炎症因子；相关性研究 　　[中图分类号] R541.4 [文献标识码] A [文章编号] 1674-4721（2014）09（c）-0050-03 　　Study the relationship and significance of insulin resistance and inflammation factors in coronary heart disease patients 　　YAN Jie1 ZHENG Xia2 　　1.Department of Cardiology，People′s Hospital of Longkou City in Shandong Province，Longkou 265701，China；2.Department of Cardiology，Traditional Chinese Hospital of Huangdao District in Qingdao City，Qingdao 266500，China 　　[Abstract] Objective To study the relationship of insulin resistance and inflammation factors in coronary heart disease （CHD） patients. Methods 120 patients in Department of Cardiology in our hospital were selected as the research object，they were divided into grouped according to the situation of patients with coronary angiography and sugar tolerance.40 cases in control group （coronary artery and the glucose tolerance of normal），40 cases in observation group Ⅰ （only CHD） and 40 cases in observation group Ⅱ （coronary heart disease complicated with abnormal glucose tolerance）.Fasting venous blood collected 5 ml in tested on the same day，The FBG，2 h BG，lipid and other project numerical were detected by automatic biochemical analyzer.The content of insulin was detected by immune method.The insulin resistance quality IRI was computed according to the formula.CRP content were detected by light scattering turbidimetric method.Coronary angiography and left，right coronary artery stenosis were evaluated according to the diamete