右旋龙脑_环糊精包合物稳定性和溶出度的研究.docVIP

———————————————————————————————————————————————右旋龙脑_环糊精包合物稳定性和溶出度的研究 ? 2196 ?中华中医药杂志(原中国医药学报)2012年8月第27卷第8期 CJTCMP,August 2012,Vol.27,No.8 ?研究报告? 右旋龙脑-β-环糊精包合物稳定性和溶出度的研究 苏健裕，陈建平，李冰，李琳 （华南理工大学轻工与食品学院，广州 510640） 摘要：目的：对右旋龙脑-β-环糊精包合物的稳定性和溶出速率进行考察。方法：采用气相色谱法，以右旋龙脑含量测定为指标，分别对右旋龙脑-β-环糊精包合物和混合物进行挥发性试验、热稳定性试验、抗光解试验和溶出度试验。结果：在光和热的影响下，包合物中右旋龙脑的挥发速率要明显小于混合物。溶出度实验表明，包合物的溶出速率明显快于混合物。结论：右旋龙脑被包合后，其稳定性明显优于单纯的右旋龙脑，便于长久贮存而不改变疗效。并且右旋龙被包合后，其体外溶出速率有显著的提高，便于发挥其药效。 关键字：右旋龙脑；β-环糊精；包合物；稳定性；溶出度 基金资助：广东省自然科学基金博士启动项目（No.10451064101005160），省部产学研结合项目（No.2009A090100041，No.2010B090500033 ），中央高校基本科研业务费专项资金（No.2011ZM0099） Study on stability and dissolution of inclusion complex of D-borneol with β-cyclodextrin SU Jian-yu, CHEN Jian-ping, LI Bing, LI Lin ( College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China ) Abstract: Objective: To study the stability and dissolution of inclusion complex of D-borneol with β-cyclodextrin. Methods: Through the volatility test, thermal stability test, anti-photodecomposition test and dissolution test, the stability and dissolution of D-borneol-β-cyclodextrin inclusion complex and physical mixture was studied by determining the changes of D-borneol contents by gas chromatography (GC). Results: Under the in? uences of light and heat, the volatile rate of D-borneol of inclusion complex was slower than physical mixture. Meanwhile, the dissolution rate of inclusion complex was faster than physical mixture. Conclusion: D-borenol-β-cyclodextrin inclusion complex had certain anti-photodissociation and thermal stability and was more stable than D-borneol alone. It could be stored longer without changing therapeutic effect. And in vitro dissolution rate of inclusion complex was improved signi? cantly. Key words: D-borneol; β-cyclodextrin; Inclusion complex; Stability; Dissolution Fund assistance: Doctor Lanch Project of Natural Science Foundation of Guangdong Province(No.1045106410