执业医师论文范文及写作的的技巧学习.docVIP

医学论文发表——创新医学网执业医师范文多种耐药基因蛋白在乳腺癌和三阴乳腺癌中表达差别的研究作者：xxx 作者单位： 石家庄市，白求恩国际和平医院病理科　　【摘要】 目的 比较分析多种耐药相关基因蛋白在乳腺癌和三阴乳腺癌表达差别，进一步了解三阴乳腺癌的耐药特性，为临床治疗三阴乳腺癌选择化疗方案提供依据。方法 选取术前未行化疗及内分泌治疗的的62例乳腺癌标本，其中三阴乳腺癌病例20例。采用免疫组化方法检测LRP、p170、谷胱甘肽S转移酶(GSTπ)、TopoⅡa在乳腺癌、三阴乳腺癌、非三阴乳腺癌中表达差别。结果 p170、LRP、GSTπ、TopoⅡa四种耐药基因相关蛋白在所有乳腺癌病例中阳性表达率分别为41.94%，59.68%，56.45%，62.90%，p170、LRP、GSTπ、TopoⅡa在非三阴组与三阴组阳性表达率分别为和40.48%，59.52%，47.62%，57.14%和45.00%，60.00%，75.00%，75.00%，其中GSTπ在2组中的表达差异有统计意义(P0.05)。2组乳腺癌中多基因共表达率分别为40.00%、11.90%，差异有统计学意义(P0.05)。结论 初治乳腺癌中存在多个耐药基因蛋白表达及共表达，三阴乳腺癌比非三阴乳腺癌化疗耐药性强，化疗效果不如非三阴组敏感。GSTπ表达强于非三阴组，提示三阴乳腺癌预后较差，化疗不敏感。　　【关键词】 乳腺癌,三阴乳腺癌,耐药基因蛋白,LRP;p170;GSTπ;TopoⅡa　　【Abstract】 Objective To investigate the different expression of several different types of drug resistance associated protein between breast carcinoma and triple negative breast carcinoma,and to explore the characteristics of drug resistance protein of triple negative breast carcinoma. Methods The expressions of drug resistance associated protein p170,LRP,GSTπ,TopoⅡa were detected in 62 cases of breast carcinoma without chemotherapy and endocrine therapy, including 20 cases of triple breast carcinoma and 40 cases of nontriple breast carcinoma by immunochemistry.Results The positive rates of p170, LRP,GSTπ,TopoⅡa in 62 cases of breast carcinoma were 41.94%,59.68%,56.45%, 62.90% respectively,which in nontriple negative breast carcinoma group were 40.48%,59.52%, 47.62%,57.14% respectively,and the positive rate in triple negative breast carcinoma group were 45.00%,60.00%,75.00%,75.00% respectively. The positive expression of GSTπ in triple negative breast carcinoma group was significantly higher than that in nontriple negative breast carcinoma group (P0.05). The coexpression of drug resistance protein in triple negative breast carcinoma group was significantly higher than that in nontriple negative breast carcinoma group (P0.05). Conclusion The expression and coexpression of drugresistance protein exist in initialtreated breast carcinoma