沙丁胺醇布地奈德联合异丙托溴铵治疗婴幼儿哮喘临床观察.doc

沙丁胺醇布地奈德联合异丙托溴铵治疗婴幼儿哮喘临床观察 　　【摘要】 目的 探讨沙丁胺醇、布地奈德联合应用异丙托溴铵雾化吸入治疗婴幼儿哮喘的临床疗效。方法 纳入婴幼儿哮喘急性发作患者100,随机分为两组,治疗组和对照组各50例。对照组在基础治疗同时,给予沙丁胺醇、布地奈德雾化吸入治疗;治疗组在对照组治疗基础上,加用异丙托溴铵雾化吸入治疗。结果 治疗组总有效率明显高于对照组,差异有统计学意义(P0.05)。所有患儿在治疗期间均未出现不良反应事件。结论 沙丁胺醇、布地奈德联合应用异丙托溴铵雾化吸入治疗婴幼儿哮喘急性发作,安全有效,值得在基层医院推广应用。 　　【关键词】沙丁胺醇;布地奈德;异丙托溴铵;婴幼儿哮喘 　　Budesonide combined salbutamol ipratropium bromide in infants with asthma clinical observation 　　LIN Dong-hao.Department of Pediatrics,People’s Hospital of Puning City,Guangdong,Puning 513000,China 　　【Abstract】 Objective To explore salbutamol,budesonide combined with ipratropium bromide inhalation in infants with asthma clinical effect.Methods Infants included 100 patients with acute asthma were randomly divided into two groups,treatment group and control group of 50 patients.The control group in the basic treatment of the same time,given salbutamol,budesonide inhalation therapy; treatment group based on the therapy in the control group,plus spray with ipratropium bromide inhalation.Results The total effective rate of treatment group was significantly higher than the control group,the difference was statistically significant(P0.05).All children were not there during the treatment adverse events.Conclusion Salbutamol,Budesonide combined with ipratropium bromide inhalation in infants with acute asthma attack,safe and effective,it is worth popularization and application of the hospital at the grassroots level. 　　【Key words】Salbutamol; Budesonide; Ipratropium bromide; Infants asthma 　　 　　婴幼儿哮喘是儿童时期最常见的呼吸道慢性疾病之一。2000年调查我国0~14岁城市儿童的患病率为0.5%~3.4%[1],其发病率有逐年上升的趋势。由于哮喘常反复发作,严重影响患儿的身心健康,也给患儿家长带来了沉重的经济负担和精神压力。急性发作时采用多种措施缓解支气管痉挛,改善肺通气功能,控制感染。我院自2008年1月至2009年12月采用沙丁胺醇、布地奈德联合应用异丙托溴铵雾化吸入治疗婴幼儿哮喘急性发作,取得较好疗效,现报告如下。 　　1 对象和方法 　　1.1 对象 选取2007年1月至2008年9月于我院住院治疗婴幼儿哮喘急性发作患者100例,诊断标准参照文献[1]。将纳入患者随机分为两组,治疗组和对照组各50例。治疗组男21例,女29例,年龄8~53月,平均22.4月;对照组男24例,女26例,年龄6~62月,平均27.3月。所有纳入患者均处于哮喘的急性发作期,临床表现:面色苍白,嘴唇发绀,鼻翼煽动,胸部三凹征,可闻喘鸣音,干湿性?音。排除标准:呼吸衰竭、心力衰竭等并发症及先天性心脏病、结核、支气管异物等疾病。均取得患儿家长知情同意。治疗前两组患儿在性别