临床医学专业-ACEI在心血管病中的应用-final.pptVIP

心脏结局预防评价研究(Heart Outcomes Prevention Evaluation Study ） A large, simple, randomized trial of Ramipril and vitamin E in patients at high risk for cardiovascular events HOPE:基线特征 HOPE:主要终点 Ramipril (%) Plac (%) RR 95% CI p No. Rand. 4645 4652 1 ° Outcome MI,Stroke,CVDth 14.1 17.7 0.78 0.70-0.86 0.000002 CV Death* 6.1 8.1 0.75 0.64-0.87 0.0002 MI* 9.9 12.2 0.80 0.71-0.91 0.0005 Stroke* 3.4 4.9 0.69 0.56-0.84 0.0003 Non-CV Death 4.3 4.1 1.03 0.84-1.25 0.78 Mortality 10.4 12.2 0.84 0.75-0.95 0.0058 *not mutually exclusive Ramipril (%) Placebo (%) Ramipril vs Placebo RR 95% C