缺血-再灌注损（Ischemia-reperfusioninjury).pptVIP

Ischemia-Reperfusion Injury and Free RadicalsJianzhong Sheng MD PhD In 1955，Sewell et al., reported that ventricular fibrillation occurred in dogs when sudden return of blood flow to the coronary artery that was ligated Myocardial reperfusion injury was first postulated in 1960 by Jennings et al. in their description of the histologic features of reperfused ischemic canine myocardium. 1967，Bulkley and Hutchins found that reflow of blood induced necrosis of cardiac myocytes after coronary artery bypass graft surgery. 1981, Greenberg confirmed that reperfusion induced severe damage of the