表柔比星法玛新乳腺癌治疗ppt课件.ppt

高血压危险因素评估及防治新进展结核病防治临床技能竞赛防控部分培训老痴呆康复训练系统项目计划书雷替曲塞在结直肠癌肝转移及原发性肝癌介入治疗中的应用颅脑损伤和急性脑血管意外的急救护理麻疹疫情调查与处置技术指南 目录 含法玛新?FEC/CEF方案是NCCN指南和St Gallen共识推荐的早期乳腺癌辅助治疗的基础方案1，2 FEC100相比FEC50显著提高10年无病生存率和总生存率3 FEC100的迟发性心脏毒性和继发性恶性肿瘤发生率与FEC50无显著差异3 1. NCCN Clinical Practice Guidelines in Oncology?；Breast Cancer ；V.2.2007 3. Jacques Bonneterre, Henri Roché, et al. Epirubicin Increases Long-Term Survival in Adjuvant Chemotherapy of Patients With Poor-Prognosis, Node-Positive, Early Breast Cancer: 10-Year Follow-Up Results of the French Adjuvant Study Group 05 Randomized Trial. J Clin Oncol. 2005 Apr 20;23(12):2686-93. 2. A. Goldhirsch et al. Progress and promise: highlights of the international expert consensus on the primary therapy of early breast cancer 2007. Annals of Oncology 2007；18: 1133–44 2007 St.Gallen 早期乳腺癌治疗专家共识 A. Goldhirsch et al. Progress and promise: highlights of the international expert consensus on the primary therapy of early breast cancer 2007. Annals of Oncology 2007；18: 1133–44 2007St. Gallen共识重点：重申对早期乳腺癌患者根据内分泌治疗敏感性的评价来确定合适的系统治疗方案的重要性。 A. Goldhirsch et al. Progress and promise: highlights of the international expert consensus on the primary therapy of early breast cancer 2007. Annals of Oncology 2007；18: 1133–44 内分泌治疗高度敏感 内分泌治疗敏感性不确定 内分泌治疗不敏感 2007St. Gallen共识对内分泌治疗的敏感性分类 A. Goldhirsch et al. Progress and promise: highlights of the international expert consensus on the primary therapy of early breast cancer 2007. Annals of Oncology 2007；18: 1133–44 低度危险： 淋巴结阴性并具备所有以下特征 pT≤2cm 病理分级为1级 ER和/或PgR表达 未侵犯肿瘤周边血管 无HER2/neu基因过表达或扩增 年龄≥35岁 　2007 St. Gallen共识：早期乳腺癌危险度分级 A. Goldhirsch et al. Progress and promise: highlights of the international expert consensus on the primary therapy of early breast cancer 2007. Annals of Oncology 2007；18: 1133–44 高度危险: 淋巴结阳性(1－3个淋巴结受累)，ER和PgR缺失，或HER2/neu基因过表达或扩增 淋巴结阳性（4个或4个以上淋巴结受累） 2007 St. Gallen共识:乳腺癌危险度分级 A. Goldhirsch et al. Progress and promise: highlights of the international expert consensus on the primary therapy of early bre