丙泊酚与七氟烷全麻对梗阻性黄疸患者影响的比较.docVIP

丙泊酚与七氟烷全麻对梗阻性黄疸患者影响的比较 　　[摘要] 目的 比?^在全麻术中丙泊酚靶控输注与七氟烷吸入麻醉对梗阻性黄疸患者的苏醒时间、苏醒时脑电双频指数（BIS）、拔管时间及发生术后不良反应的影响。 方法 选择2016年1月～2017年5月于广州中医药大学附属茂名市中医院全身麻醉下行上腹部手术的患者72例，均为ASA I或Ⅱ级。按血清总胆红素水平分为黄疸组和非黄疸组，每组各36例。随机将两组患者均分为丙泊酚A、B组和七氟烷A、B组，每组各18例。记录各组患者的苏醒时间、苏醒时BIS、拔管时间及术后不良反应的发生率。 结果 七氟烷A组患者苏醒时间和苏醒时BIS、拔管时间最长，丙泊酚A组患者苏醒时间和苏醒时BIS、拔管时间均短于七氟烷A组，差异有统计学意义（P 0.05）；丙泊酚B组患者苏醒时间和苏醒时BIS、拔管时间长于七氟烷B组，差异有统计学意义（P 0.05）。丙泊酚B组患者术后24 h术后恶心呕吐、头晕、嗜睡发生率明显低于七氟烷B组，黄疸组患者丙泊酚A组术后24 h术后恶心呕吐、头晕、嗜睡发生率明显低于七氟烷A组，差异均有统计学意义（P 0.05）。 结论 梗阻性黄疸患者丙泊酚靶控输注麻醉较七氟烷吸入麻醉术后恶心呕吐发生率更低，清醒更迅速，并且丙泊酚的麻醉效果比七氟烷更好。 　　[关键词] 梗阻性黄疸；丙泊酚；七氟烷；苏醒时间；术后不良反应 　　[中图分类号] R614 [文献标识码] A [文章编号] 1673-7210（2018）02（a）-0086-04 　　Comparison on the effects of Propofol and Sevoflurane on patients with obstructive jaundice during general anesthesia 　　ZHANG Xiaohua1 LI Xirong2 LI Yuchan1 ZHANG Jinxiong1 XIONG Xiang3 　　1.Department of Anesthesiology， Maoming Hospital of Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine， Guangdong Province， Maoming 525000， China； 2.Clinical Laboratory， Maoming Hospital of Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine， Guangdong Province， Maoming 525000， China； 3.Department of General Surgery， Maoming Hospital of Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine， Guangdong Province， Maoming 525000， China 　　[Abstract] Objective To compare the anesthesia of Propofol target controlled infusion and Sevoflurane inhalation anesthesia recovery time and recovery of patients with obstructive jaundice of the bispectral index （BIS）， the influence of adverse reactions and postoperative extubation time. Methods From January 2016 to May 2017， 72 patients of general anesthesia on downward abdominal surgery in Maoming Hospital of Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine， all were ASA I or Ⅱ， according to the serum level of total bilirubin they were divided into jaundice group and non jaundice group， with 36 cases in each group， then th