牛皮癣银屑病ppt课件.ppt

Psoriasis;Definition Etiology and Pathogenesis Types and Clinical Features Histopathology Diagnosis and Differential Diagnosis Treatment; Definition;Introduction;Etiology;2. Triggering factors Infection: bacteria (streptoccoci A), virus, yeast 　 Environment: trauma, surgery, pregnancy, alcohol consumption, smoking Psychological: emotional stress, death event, family problem 　 Drugs: β- blockers, angiotensin-converting enzyme inhibitors(ACEI), antimalarials, lithium;Theory After processing by antigen presentation cell, the antigen is presented to CD4 T-lymphocytes → production of cytokines → stimulate keratinocytes → proliferation and expression of adhesion molecules by endothelial cells → infiltration of leukocytes into the skin lesions; Types of Psoriasis;Psoriasis Vulgaris (寻常型银屑病);Severe Psoriasis;Lesion features: dropping wax candle (蜡滴现象) thin membrane (薄膜现象) 　　　　　 Auspitz’s sign (点状出血) Sites：extensor surface of the extremities (elbows, knees), scalp, lumbosacral area, genital region. Symptom: itching 20%　;Dropping Wax Candle (蜡滴现象) On scrapping, the white scales resembles wax candle ; Thin Membrane (薄膜现象) After removal of the scales, there is a glistening red membrane. ;Auspitz’s sign (点状出血) Upon removal of the scales, capillary bleeding points are revealed.;Lesion features: dropping wax candle (蜡滴现象) thin membrane (薄膜现象) 　　　　　 Auspitz’s sign (点状出血) Sites：extensor surface of the extremities (elbows, knees), scalp, lumbosacral area, genital region. Symptom: itching 20%　; Most common;;Lesion features: dropping wax candle (蜡滴现象) thin membrane (薄膜现象) 　　　　　 Auspitz’s sign (点状出血) Sites：extensor surface of the extremities (elbows, knees), scalp, lumbosacral area, genital region. Symptom: itching 20%　 ;Specific Types of Psoriasis Vulgaris;The lesions appear abruptly on