突变体p能够通过内源性的PDGFRb促进胰腺癌的转移ppt课件.pptVIP

Journal: Cell Reporter: XuWang IF: 33.116 Abstract Mutant p53 metastasis antiproliferative prometastatic phenotype PDGFRb p73/NF-Y metastasis invasion vitro vivo × prognostic marker Background Background 75% p53 mutant highly metastatic poor prognosis drug resistance Background KPC cell :stablely express small haipin RNA,lost remaning p53 wide-type alle KPflC cell:a p53 null cell line KPC mice: develop highly metastatic pancreatic cancer that faithfully mimics the human disease Ideas Mutant p53 maintain metastatic phenotype the relationship between Mutant p53 and PDGFRb on metastasis