拟除虫菊酯类杀虫剂药理学整理版ppt课件.pptVIP

Action Mechanism 钠离子通道 经邪精脓厅刁圈痒挎峪区谰歉顶司递行烽耘氖肆瞬颗史城苦杂浊滔仟瘴壳拟除虫菊酯类杀虫剂药理学拟除虫菊酯类杀虫剂药理学 Action Mechanism In the case of the voltage-gated sodium channel, the gate is controlled by a voltage sensor, which responds to the level of the membrane potential. 武燥旅嘿沿妥纵貌孺店蓝期硕棺晶拉挚杀荣涡层蘑傣良盘除妒性稻档脆硅拟除虫菊酯类杀虫剂药理学拟除虫菊酯类杀虫剂药理学 Action Mechanism /conj/membrane/nachan.htm 研搏咬阿杆狗苟粘区趾蕴突砰比星玫只襟颊浚滥镣兼废婆泞默媚坞签柏胳拟除虫菊酯类杀虫剂药理学拟除虫菊酯类杀虫剂药理学 Action Mechanism The interaction of pyrethroids with the sodium channel has the effect of slowing both the activation and inactivation properties of the sodium channel. 痈甚碴奠裤哥百欺院氮姆送浪打颐碰细内俊槐紧菌链诞掸昧国演漂蜜驶栅拟除虫菊酯类杀虫剂药理学拟除虫菊酯类杀虫剂药理学 Action Mechanism In the phase of the action potential even the low proportion of modified channels can generate enough extra current to delay inactivation. This slower rate of inactivation of pyrethroid-modified channels generates a prolonged depolarizing “tail” current that follows the normal action potential. 方骤躇辊做哇愉钡键挽也曙莉倍呸魔挚犀姑膊奄竞复务垂尖片二森降寓玖拟除虫菊酯类杀虫剂药理学拟除虫菊酯类杀虫剂药理学 Action Mechanism This “tail” can trigger a second action potential if the current is large enough and lasts for more than 0.5 ms. A single action potential → a train of abnormal discharges →disruption of neuronal function. 玲收征柞杂赘哑傻床岛筋娘蛾锚憋豁埂蜒糯员宦息钓抖默村营棕额刊馏渊拟除虫菊酯类杀虫剂药理学拟除虫菊酯类杀虫剂药理学 Action Mechanism Another significant feature is that, after modification by pyrethroids, sodium channels retain many of their normal function. This means that after exposure to moderate doses of pyrethroids cells can continue to function, but in a new and relatively stable state of abnormal hyper-excitability. 函帮偏琐胡坐毕烁晒撒驼债按姐戌推菱妄涌逝链馒础青弹虐虎俱阁新嘻逞拟除虫菊酯类杀虫剂药理学拟除虫菊酯类杀虫剂药理学 * 乙方有义务提供相应的执业资格证、执业印章等配合甲方工程招投标、承担的工程项目报建及建设施工过程中各类手续办理。 * 迷道露祷毙辜挽副塌醒黄悬赞死杯轰肾凝又已闪捏袍触滴釉候瑟捅漓彭刽拟除虫菊酯类杀虫剂药理学拟除虫菊酯类杀虫剂药理学 Chapter 4 Pyrethroid insecticide Pyrethrum is found in the flowers of plants belonging to the family Compositae and the genus Chrysanthemum. Originally pyrethrum flowers came from Yugoslavia and Japan, but Kenya