毛细胞白血病幻灯课件.pptVIP

HCL Variant 10% of HCL cases Similarity: age gender splenomegaly anemia etc. morphology Dissimilarity: higher white blood cell count lack of monocytopenia absent of Annex-1 CD25 BRAF V600E less durable responses to PA more aggressive IgHV 4-34 rearrangement and others MEK inhibition Classified as a separate entity by WHO 2008 Future Direction Optimizing therapy of relapsed patients role of MRD role of ongoing therapy BRAF-MEK-ERK pathway Summary rare cas classified as B-CLPD in WHO 2008