接头分子Cbl与血管再狭窄的防治课件.pptVIP

Fighting Restenosis: Targeting c-Cbl; Coronary artery disease: a significant health threat afflicting millions of individuals worldwide. Despite the development of a variety of technologies and catheter based interventions, post-procedure restenosis is still a significant concern. Gene therapy has emerged as a promising approach aimed at modifying cellular processes that give rise to restenosis. ;Gene Therapy-Preclinical Study ;c-Cbl;Aim of the Study;;PDGF Increased c-Cbl Tyrosine Phosphorylation in SMCs;A Hierarchical Signaling Cascade from c-Cbl to PI3K/akt/mTOR in SMCs;Ablation of c-Cbl