胃癌术后放疗靶区偏移定量研究及三维适形和调强照射剂量学比较-quantitative study on the deviation of radiotherapy target area after gastric cancer surgery and comparison of three-dimensional conformal and intensity-modulated radiation dosimetry.docxVIP

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胃癌术后放疗靶区偏移定量研究及三维适形和调强照射剂量学比较-quantitative study on the deviation of radiotherapy target area after gastric cancer surgery and comparison of three-dimensional conformal and intensity-modulated radiation dosimetry.docx

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胃癌术后放疗靶区偏移定量研究及三维适形和调强照射剂量学比较-quantitative study on the deviation of radiotherapy target area after gastric cancer surgery and comparison of three-dimensional conformal and intensity-modulated radiation dosimetry

Ab Abstract PAGE PAGE IV ABSTRACT Objective: To determine target movement for gastric cancer radiotherapy after operation and compare the dose distribution with three—dimension conformal radiation therapy (3D-CRT) and intensity modulated radiation therapy(IMRT) , to provide reference for clinical application. Methods: 1、Select 15 patients with gastric cancer underwent D2 radical gastrectomy in the First Affiliated Hospital of Nanchang University, to position it by CT scan,keep the patients on an empty stomach for 3 hours,then drink 400ml water 5 minutes before radiotherapy position, ensure full stomach filling,position by CT simulation scan In the Pinnacle planning system,draw the outline of the target area and the surrounding normal tissue,the physical teacher makes the plan,clinicians makes the confirmation. 2、5 minutes before plan verification,the patients drink 400ml water+10ml diatr -izoate on an empty stomach,observe gastric target mobility in thesimulation of machi ne,use the same method in radiotherapy and after radiotherapy to re observe the mobility for the gastric target area 3、select the 5 cases of postoperative gastric cancer patients as above mentioned, designed for three-dimensional conformal radiotherapy (3DCRT) and intensity-modul ated radiotherapy (IMRT) plans to compare two groups, prescription dose of 95% PT V 45Gy, 99% PTV 42.75 Gy with a prescription dose, dose curve and dose volume hi stogram (DVH) to evaluate the treatment plan, evaluation parameters including V95 %, conformal index (conformal index, CI), evenness index (homogeneity index, HI),irradiation dose and the spinal cord, liver and kidney. Results: 、 in the direction of the head and the foot,the mobility idex for the gastric cancer is maximum and is 11.76±0.46mm.in the direction of the right and the left, it PAGE PAGE V is minimum and is 5.24±0.20mm.in the direction of the back and the belly, it is 7.71±0.28mm.there is no statistics meani