Bcl2与ILK蛋白在子宫平滑肌肿瘤中表达及意义.docVIP

Bcl2与ILK蛋白在子宫平滑肌肿瘤中表达及意义 　　[摘要] 目的:探讨Bcl-2和ILK蛋白在子宫平滑肌肿瘤(USMTs)中的表达和意义。方法:对20例良性子宫平滑肌瘤(UL)、18例子宫平滑肌肉瘤(LMS)及70 例交界性子宫平滑肌瘤(BLM)[包括40例富于细胞型子宫平滑肌瘤(CL)、13例奇异型子宫平滑肌瘤(BL)、4例核分裂活跃型子宫平滑肌瘤(ML)、10例不典型子宫平滑肌瘤(AL)及3例恶性潜能未定型子宫平滑肌瘤(STUMP)]应用免疫组织化学法检测Bcl-2 和ILK蛋白的表达。结果:UL组Bcl-2蛋白表达阳性率明显高于LMS组(P0.05);BLM 组Bcl-2蛋白表达阳性率显著高于LMS组(P0.01);LMS组ILK蛋白表达阳性率显著高于UL组(P0.01)和BLM组(P0.01)。结论:Bcl-2和ILK蛋白的过度表达可能在ULMTs的发生、发展中起重要作用。 　　[关键词] 子宫肿瘤;平滑肌瘤;Bcl-2蛋白;ILK蛋白 　　[中图分类号] R737.33 [文献标识码]B [文章编号]1674-4721(2010)03(c)-066-03 　　 　　Expression and significance of Bcl-2 and ILK protein in human uterine smooth muscle tumors 　　JIANG Ze1,LI Chunling2,LI Shengshui3*,LIU Chunzai4,ZHANG Fengmei3,XU Hua3,LIU Yan3,LI Shuangbiao3 　　(1.Cangzhou Central Hospital,Cangzhou 061001,China; 2.Cangzhou Women and Childrens Healthcare Hospital,Cangzhou 061001,China; 3.Cangzhou Hospital for Integrated Chinese and Western Medicine,Cangzhou 061001,China; 4.Nan Da Gang Hospital, Cangzhou 061103,China) 　　[Abstract] Objective:To investigate the expression and significance of Bcl-2 and ILK prostein in human uterine smooth muscle tumors(USMTs). Methods:Immunohistochemical technique was used to detect the Bcl-2 and ILK protein expressions in 20 usual leiomyoma(UL),70 borderline leiomyoma(BLM)[including 40 cellular leiomyoma(CL),13 bizarre leiomyoma(BL),4 mitotically active leiomyoma(ML),10 atypial leiomyoma(AL),3 smooth muscle tumors of uncertain m alignant potential(STUMP)]and 18 leiomyosarcoma(LMS). Results:The positive Bcl-2 protein expressin rate of UL was apparently higher than that ofLMS(P0.05);The positive Bcl-2 protein expression rate of BLM was clearly higher than that ofLMS(P0.01);The positive ILK protein expression rate of LMS was clearly higher than that ofUL(P0.01)and BLM(P0.01).Conclusion:The results suggest that an inhibition of induction of apoptosis,either by Bcl-2 or by ILK protein overexpression may play an important role in human uterine smooth muscle tumors. 　　[Key words] Uterin neoplasm; Smooth muscle tum