SIRT1p53在卵巢浆液性肿瘤中表达及意义.docVIP

SIRT1p53在卵巢浆液性肿瘤中表达及意义 　　 【摘要】 目的：探讨SIRT1、p53蛋白在卵巢浆液性肿瘤中的表达，分析其在卵巢浆液性癌发生发展中的作用。方法：应用Envision二步免疫组织化学方法检测SIRT1、p53在41例卵巢浆液性囊腺癌，26例卵巢交界性浆液性囊腺瘤，28例卵巢浆液性囊腺瘤中的表达。结果：(1)SIRT1、p53在卵巢浆液性囊腺癌，卵巢交界性浆液性囊腺瘤，卵巢浆液性囊腺瘤中阳性表达差异有统计学意义(P0.05)；(2)SIRT1在卵巢浆液性囊腺癌低分化组的表达高于高分化组，在淋巴结阳性组的表达明显高于淋巴结阴性组(P0.05)。(3)SIRT1与p53无明显相关性。结论：SIRT1在卵巢浆液性癌中高表达。且在病理高级别及淋巴结阳性组的患者中的表达较高，提示SIRT1在肿瘤的发生发展中起到了促进作用。 　　 【关键词】 组蛋白去乙酰化酶SIRT1； p53； 卵巢浆液性癌 　　 　　 Expression and significance of SIRT1、p53 in serous ovarian tumors/DU Guo-qing，ZHANG Wei./Medical Innovation of China，2012，9(13):008-010 　　 【Abstract】 Objective:To study the expression of SIRT1， p53 protein in serous ovarian tumors， and analyze its role in the development of ovarian serous carcinoma.Methods:Envision immunohistological method were adopted to examine the expression of SIRT1， p53 and compared between the ovarian serous adenocarcinoma(n=41)， and the borderline ovarian serous cystadenoma(n=26)，and the ovarian serous cystadenoma(n=28). Results:(1)The positive rates of SIRT1、p53 were in the ovarian serous adenocarcinoma， the borderline ovarian serous cystadenoma， the ovarian serous cystadenoma. Compared with each group， expression of SIRT1 was significantly enhanced(P0.05)；(2)the positive expression rate of SIRT1 in ovarian serous adenocarcinoma poorly-differentiated group was higher than Well-differentiated groups， expression was statistically significant， expression in node-positive group was significantly higher than the lymph node-negative group (P0.05).(3)There was no significant correlation between SIRT1 and p53.Conclusion:SIRT1 is high expression in ovarian serous carcinoma， And higher expression in patients with pathological high-level and node-positive group， Prompt SIRT1 play a catalytic role in tumor development. 　　 【Key words】 Silent information regulator factor SIRT1； p53； Serous ovarian carcinoma 　　 First-author’s address: Urumqi City Maternal and Child Health Hospital，Urumqi 830054，China 　　 doi:10.3969/j.issn.1674-4985.2012.13.00