乳果糖口服液治疗慢性肾功能不全临床观察.docVIP

乳果糖口服液治疗慢性肾功能不全的临床观察 　　摘 要 目的：观察乳果糖口服液治疗慢性肾功能不全的临床疗效。方法：收集2014年7月―2015年7月慢性肾功能不全患者38例，随机分为治疗组20例，采用乳果糖口服液治疗，对照组18例采用包醛氧淀粉治疗，两组均治疗8周。观察两组治疗后症状评分、血肌酐、尿素、尿酸指标的变化。结果：治疗组总有效率为45.0%（9/20），对照组为44.4%（8/18），组间差异无统计学意义（P0.05）。两组治疗后症状、体征和肾功能均较治疗前改善（P0.05）。结论：乳果糖口服液治疗轻、中度慢性肾功能不全有较好疗效。 　　关键词 慢性肾功能不全 乳果糖口服液 包醛氧淀粉 　　中图分类号：R692 文献标志码：A 文章编号：1006-1533（2016）10-0029-03 　　Observation of the clinical efficacy of lactulose oral solution in the treatment of chronic renal insufficiency 　　ZHANG Yu1， CHU Suping1， FU Qiong2（1. Xingchang Community Health Service Center of Pudong New District， Shanghai 201314， China； 2. Medical School of Tongji University， 　　Shanghai 200092， China） 　　ABSTRACT Objective： To observe the clinical efficacy of lactulose oral solution in the treatment of chronic renal insufficiency. Methods： From July 2014 to July 2015， 38 cases of chronic renal insufficiency were collected and randomly divided into a treatment group with 20 cases and a control group with 18 cases. The treatment group was treated with lactulose oral solution， the control group with coated aldehyde oxystarch， and both of them were treated for 8 weeks. The changes of the symptom scores and indexes of serum creatinine， urea and uric acid were observed in the two groups after the treatment. Results： The total effective rate was 45%（9/20） in the treatment group and 44.4%（8/18） in the control group. The differences between the two groups had no statistical significance（P0.05）. The symptoms， signs and renal function were improved in both groups after treatment （P0.05）. Conclusion： Lactulose oral solution has the good effect in the treatment of mild and moderate chronic renal insufficiency. 　　KEY WORDS chronic renal insufficiency； lactulose oral solution； coated aldehyde oxystarch 　　慢性肾功能不全是各种病因所致肾脏损害和进行性恶化的结果，临床表现为恶心、纳差、呕吐、乏力、骨痛等，与肾脏滤过功能下降、代谢废物和一些毒性物质如尿素、肌酐的代谢产物胍类等不能排出体外有关[1-2]。在慢性肾功能不全非透析治疗阶段，经肠道吸附、排出毒素的肠道清除疗法是常用方法之一，临床常用药物有包醛氧淀粉[3]、药用活性炭和一些中成药方剂[4]。乳果糖口服液能促进肠道内氨及其他毒素排泄，是治疗肝性脑病和肝性脑病前期[5-6]的常用辅助药物