克罗米芬与定坤丹对PCOS不孕症临床促排卵和临床妊娠疗效研究.docVIP

克罗米芬与定坤丹对PCOS不孕症临床促排卵和临床妊娠疗效研究 　　[摘要]评价在克罗米芬（CC）+促性腺激素（Gn）基础上，CC与定坤丹对PCOS不孕症患者临床促排卵和临床妊娠疗效的研究，为中药助孕治疗提供思路和方法。选择2015年10月1日―2017年4月23日在江苏省中医院生殖医学科门诊行促排卵治疗的PCOS不孕症患者60例。按随机数字表法分为A组[CC+Gn+人绒毛膜促性腺激素（HCG）]和B组（CC+Gn+定坤丹）。观察周期排卵率、周期取消率、周期妊娠率、累积妊娠率、排卵日子宫内膜厚度、Gn使用天数和总用量、未破裂卵泡黄素化综合征（LUFS）及卵巢过度刺激综合征（OHSS）发生率。A组的周期排卵率、周期妊娠率、累积妊娠率及排卵日子宫内膜厚度均小于B组，而周期取消率、Gn使用天数及总用量均大于B组，且差异均具有统计学意义（P005）。该研究未出现1例LUFS或OHSS。CC与定坤丹对PCOS不孕症患者具有促排效应，且CC+Gn+定坤丹联合促排方案能显著提高临床妊娠率。 　　[关键词]定坤丹； 多囊卵巢综合征； 克罗米芬 　　[Abstract]The evaluation is based on clomiphene citrate （CC）+gonadotropin （Gn）， clinical study on CC and Dingkun Dan′s treatment on ovulation induction and clinical pregnancy effect of PCOS， and to provide ideas and methods for traditional Chinese medicine assisted reproductive treatment This study selected 60 PCOS infertility patients treated with ovulation induction in reproductive medicine clinic， Jiangsu Province Hospital of traditional Chinese medicine during20170423 They were randomly divided into two groups： Group A （CC+Gn+HCG） and Group B （CC+Gn+Dingkun Dan） These results were observed and compared including cycle ovulation rate， cycle cancellation rate， cycle pregnancy rate， cumulative pregnancy rate， endometrial thickness， duration of Gn， total amount of Gn， the occurring rate of luteinized unruptured follicle syndrome and ovarian hyperstimulation syndrome Group A had lower cycle ovulation rate， cycle pregnancy rate， cumulative pregnancy rate and endometrial thickness， compared with Group B， the difference was statistically significant（P005） However， Group A had higher cycle cancellation rate， duration of Gn and total amount of Gn， compared with Group B， the difference was statistically significant（P005） In this study， no case of LUFS or OHSS was found in all patients CC and Dingkun Dan had the effect of promoting ovulation on PCOS infertility patients， and CC+Gn+Dingkun Dan could elevate clinical pregnancy rate. 　　[Key words]Dingkun Dan； polycystic ovary syndrome； clomiphene ci