前列地尔配合常规治疗对糖尿病下肢血管病变患者炎症因子和氧化应激影响.docVIP

前列地尔配合常规治疗对糖尿病下肢血管病变患者炎症因子和氧化应激影响 　　【摘要】 目的：探?选择前列地尔联合常规疗法对糖尿病下肢血管病变患者炎症因子以及氧化应激的影响。方法：选取2015年12月-2017年9月本院收治的糖尿病下肢血管病变患者80例，通过数字奇偶法将其分为对照组和观察组，各40例。对照组采用常规治疗，观察组采用前列地尔+常规治疗，两组均治疗14 d。比较两组治疗前后的临床症状评分、踝肱指数（ankle brachial index，ABI）、氧化应激指标水平、炎症细胞因子水平、疼痛程度（VAS评分），观察两组治疗效果。结果：治疗后，观察组ABI高于对照组及治疗前，临床症状评分低于对照组及治疗前，比较差异均有统计学意义（P0.05）；治疗后，观察组疼痛程度评分低于对照组（P0.05）；观察组总有效率为97.50%，高于对照组的72.50%（ 字2=9.803 9，P=0.001 7）。结论：合理选择前列地尔+常规疗法对糖尿病下肢血管病变患者进行治疗，可以有效改善患者下肢血流以及临床症状表现，充分降低其氧化应激反应水平，但是针对患者体内炎性细胞因子无显著性影响。 　　【关键词】 前列地尔； 糖尿病下肢血管病变； 炎症因子； 氧化应激 　　Effects of Alprostadil Combined with Conventional Treatment on Inflammatory Factors and Oxidative Stress in Patients with Diabetic Lower Extremities Vascular Disease/ZHANG Xutian，CHEN Zhixiong，ZHANG Min，et al.//Medical Innovation of China，2018，15（03）：007-010 　　【Abstract】 Objective：To investigate the influence of Alprostadil combined with conventional treatment on inflammatory factors and oxidative stress in patients with diabetic lower extremities vascular disease.Method：A total of 80 patients with diabetic lower extremity vascular disease were treated in our hospital from December 2015 to September 2017 were selected.They were divided into control group and observation group by the digital odd and even method，40 cases in each group.The control group was treated with conventional treatment，and observation group was treated with Alprostadil combined with conventional treatment，they were treated with 14 d.The clinical symptom score，ankle brachial index（ABI），oxidative stress index，inflammatory cytokine level and degree of pain（VAS score） between two groups before and after treatment were compared，and the clinical effects of two groups was observed.Result：After treatment，the ABI in observation group was higher than those of control group and before treatment，the clinical symptom score was lower than those of control group and before treatment，the differences were statistically significant（P0.05）.After treatment，the score of pain in observatio