坤泰胶囊对排卵障碍性不孕症患者卵泡发育子宫内膜及排卵影响.docVIP

坤泰胶囊对排卵障碍性不孕症患者卵泡发育子宫内膜及排卵影响 　　【摘要】 目的 探讨中成药坤泰胶囊对排卵障碍性不孕症患者卵泡发育、子宫内膜及排卵的影响。方法 选取排卵障碍性不孕症患者210例， 随机分成A、B、C三组， 各70例。A组口服坤泰胶囊， B组口服克罗米芬， C组口服坤泰胶囊+克罗米芬， 观察三组患者的卵泡大小、数目、子宫内膜厚度及类型。出现成熟卵泡再重新分组， Ⅰ组口服坤泰胶囊， 直至排卵， Ⅱ组肌内注射人绒毛膜促性腺激素（HCG）， 观察两组患者排卵及卵泡黄素化情况。结果 B、C两组成熟卵泡数、排卵率均高于A组， 差异具有统计学意义（P0.05）。A、C两组子宫内膜厚度及类型优于B组， 差异有统计学意义（P0.05）。Ⅰ、Ⅱ两组血清雌二醇（E2）≥3000 pg/ml的例数和排卵率， 差异无统计学意义（P0.05）， Ⅰ组卵泡黄素化率明显小于Ⅱ组， 差异有统计学意义（P0.05）。结论 坤泰胶囊对卵子发育成熟、改善子宫内膜容受性、卵子排出具有明显效果。 　　【关键词】 不孕症；排卵障碍；坤泰胶囊；克罗米芬；人绒毛膜促性腺激素；疗效 　　DOI：10.14163/j.cnki.11-5547/r.2015.18.005 　　Influence by Kuntai capsule on follicular development， endometrium and ovulation in ovulation failure infertility patients WU Cui-jie. Department of Obstetrics and Gynecology， Anyang City Hospital of Traditional Chinese Medicine， Anyang 455000， China 　　【Abstract】 Objective To investigate the influence of Chinese patent medicine Kuntai capsule on follicular development， endometrium and ovulation in ovulation failure infertility patients. Methods A total of 210 ovulation failure infertility patients were randomly divided into groups A， B and C， with 70 cases in each group. Group A received Kuntai capsule through oral administration， group B received clomiphene through oral administration， and group C received Kuntai capsule+clomiphene through oral administration. Size， number of follicular， thickness and type of endometrium were observed in the three groups. Patients with mature follicle were divided into new groups. Group Ⅰ received Kuntai capsule through oral administration till ovulation， and group Ⅱ received human chorionic gonadotropin （HCG） through intramuscular injection. Ovulation and follicle luteinization were observed in the two groups. Results Groups B and C had higher mature follicle number and ovulation rate group A， and their difference had statistical significance （P0.05）. Groups A and C had better thickness and type of endometrium， and the difference had statistical significance （P0.05）. The difference of cases with serum estradio