骨骼肌1型11β－羟基类固醇脱氢酶在2型糖尿病发病机制中的作用.PPT

Test What is mechanism of antimicrobial action and corresponding antimicrobial agents? What is the mechanism of bacterial resistance to an antimicrobial agent? Which drug is first chosen to treat penicillin allergic shock, and why? What are features in three generations of cephalosporins? What are antibacterial spectrum and clinical uses of erythromycin? What is antibacterial action of quinolones? What is composition of co-trimoxazole and adventage of co-trimoxazol? Which species are anticancer agents divided into, according to biochemistry mechanisms of antitumor effect? Which antibacterial agents are contraindicated in treatment of newborn infection and why? Which drug is used for treatment of infection caused by staphylococcus aureus? * Anticancer Drug Section I Basic Pharmacology of Anticancer Drug 1. Classification (1) According to chemical constitution and resource Alkylating agent Antimetabolites Antibiotics Plant-derived products Hormonal agent Alkylating agent Cyclophosphamide Mechlorethamine Melphalan Chlorambucil Antimetabolites Folic acid analogue: methotrexate Pyrimidines:fluorouracil, cytarabine Purines: thioguanine, mercaptopurine Antibiotics Anthracyclines Dactinomycin Bleomycin Mitomycin Plant-derived products Vinca alkaloids Etoposides Taxanes Hormone antagonists Hormone agonists Hormonal agent （2）According to biochemistry mechanisms of antitumor effect Agents affecting biosynthesis of nucleic acid Agents affecting structure and function of DNA Agents affecting transcription process and interrupting synthesis of RNA Agents interfering with the formation and function of proteins. Agents affecting hormone homeostasis 2. Mechanism of pharmacologic action （1） Cell biology mechanisms of antitumor effect （2） Biochemistry mechanisms of antitumor effect （1） Cell biology mechanism of antitumor effect Cell Cycle-Nonspecific (CCNS) Agents: Alkylating agent, Antibiotics, Platinum antitumor compound Cell Cycle-Specific (CCS) Agents: