多沙唑嗪缓释片改善输尿管支架管相关症状非随机―对照研究.docVIP

多沙唑嗪缓释片改善输尿管支架管相关症状非随机―对照研究 　　[摘要] 目的 探讨多沙唑嗪缓释片改善输尿管支架管相关症状的效果。 方法 将2014年3～9月我院58例泌尿系结石术后留置输尿管支架管的患者分为试验组和对照组，试验组24例，对照组34例。对照组术后1～3 d拔除尿管，口服抗生素预防感染，术后2～4周拔除输尿管支架管；试验组在对照组基础上，口服甲磺酸多沙唑嗪缓释片4 mg，1次/d，2～4周。拔管前独立完成国际前列腺症状评分（IPSS）、生活质量评估（QOL）、视觉模拟量表评分（VAS）评分问卷。 结果 试验组IPSS评分与对照组比较，差异有统计学意义[（9.12±0.99）分 vs （11.65±1.39）分，t=7.616，P=0.000]；QOL评分与对照组比较，差异有统计学意义[（2.21±0.59）分 vs （2.68±0.84）分，t=2.345，P=0.023]；VAS评分与对照组比较，差异有统计学意义[（1.54±0.59）分 vs （1.97±0.67）分，t=2.514，P=0.015]；血尿发生率与对照组比较，差异无统计学意义（37.50% vs 44.12%，χ2=0.254，P=0.614）。 结论 多沙唑嗪控释片可改善输尿管支架管相关症状以及患者的生活质量。 　　[关键词] 多沙唑嗪缓释片；支架管相关症状；泌尿系结石 　　[中图分类号] R697.3 [文献标识码] A [文章编号] 1674-4721（2016）05（a）-0148-03 　　Non randomized controlled study on Doxazosin Sustained Release Tablets in improving associated symptoms of urethral stent 　　ZHANG Nan KONG Su-fang GE Lei GUO Liang MA Yao-hui QU Xiao-wei SHAN Zhong-jie 　　Department of Urology Surgery，Zhengzhou People′s Hospital，Zhengzhou 450003，China 　　[Abstract] Objective To discuss the effect of Doxazosin Sustained Release Tablets in improving associated symptoms of urethral stent. Methods 58 patients with urethral stent after operations due to urinary calculus treated in our hospital from March to September 2014 were selected and divided into study group （n=24） and control group （n=34）.For patients in the control group，catheters were removed after 1-3 days of operation，antibiotics were orally administrated for infection prevention，and urethral stents were removed after 2-4 weeks of operation.Patients in the study group were additionally orally given Doxazosin Mesylate Sustained Release Tablets 4 mg，qd，for 2-4 weeks.IPSS，QOL，and VAS scales were accomplished separately before removing the stents. Results There were significant differences in IPSS scores，QOL scores and VAS scores [（9.12±0.99） scores vs （11.65±1.39） scores，t=7.616，P=0.000；（2.21±0.59） scores vs （2.68±0.84） scores，t=2.345，P=0.023；（1.54±0.59） scores vs （1.97±0.67） scores，t=2.514，P=0.015] between the study group and the cont