妊娠晚期甲状腺功能异常与体质量指数相关性分析.docVIP

妊娠晚期甲状腺功能异常与体质量指数相关性分析 　　[摘要]目的 分析妊娠晚期甲状腺功能异常与体质量指数的相关性。方法 选取2015年1～12月入院分娩的274例甲状腺功能正常孕妇为对照组，同期的97例妊娠期临床甲状腺功能减退孕妇（甲减组），160例低甲状腺素血症（低甲状腺素组），192例亚临床甲状腺功能减退（亚甲减组），研究四组孕妇游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺素（TSH）及体质量指数（BMI）情况。结果 甲减组BMI和TSH均高于对照组，FT3和FT4均低于对照组，差异有统计学意义；低甲状腺素组BMI高于对照组，TSH、FT3和FT4均低于对照组，差异有统计学意义；亚甲减组BMI、FT3、FT4与对照组相比较，差异无统计学意义，仅TSH低于对照组，差异有统计学意义；在四组中，FT3与BMI呈正相关，FT4与BMI呈负相关，相关性有统计学意义，TSH与BMI相关性无统计学意义。结论 高BMI孕妇易在妊娠晚期出现低甲状腺素血症和临床甲状腺功能减退，其具体机制有待于进一步研究。 　　[关键词]甲状腺功能减退；低甲状腺素血症；亚临床甲状腺功能减退；体质量指数；妊娠 　　[中图分类号] R714.256 [文献标识码] A [文章编号] 1674-4721（2016）07（c）-0078-04 　　[Abstract]Objective To analyze the correlation of thyroid dysfunction and body mass index in late pregnancy. Methods 274 cases euthyroid （control group），97 cases clinical hypothyroidism （hypothyroidism group），160 cases hypothyroxinemia （hypothyroxinemia group） and 192 cases subclinical hypothyroidism （subclinical hypothyroidism group） pregnant women were recruited in our hospital from January and December 2015.The concentrations of FT3，FT4，TSH and BMI were researched.Results In hypothyroidism group，BMI and TSH were significantly higher than those in the control group （P 0.05），FT3 and FT4 were significantly lower than those in the control group；In hypothyroxinemia group，BMI were significantly higher than that in the control group，TSH，FT3 and FT4 were significantly lower than those in the control group；There were no difference in BMI，FT3 and FT4 between subclinical hypothyroidism group and the control group，but TSH was significantly higher in subclinical hypothyroidism group；In four groups，FT3 was positively associated with BMI，FT4 was negatively associated with BMI，but relations between TSH and BMI was not statistically significant.Conclusion High BMI during in late pregnancy is more liable to develop hypothyroxinemia and clinical hypothyroidism，but the detailed mechanism need to be studied further. 　　[Key words]Hypothyroidism；Hypothyroxinemia；Subclinical hypothyroidism；Body mass index；Pregnancy 　　甲状