右旋布洛芬盐酸改性蒙脱土的制备与体外释放研究.docVIP

右旋布洛芬/盐酸改性蒙脱土的制备及体外释放研究 李婷婷，赵乐乐，张敏，田青平，张淑秋 （山西医科大学 药学院， 山西 太原 030001） 摘要：为了提高右旋布洛芬的载药量，并探索载药复合物在不同释放介质中的释放规律，本文以盐酸改性蒙脱土为药物载体，用溶液插层法将右旋布洛芬负载于酸化后的蒙脱土上，制得右旋布洛芬/酸改性蒙脱土复合物，利用XRD、BET、SEM对蒙脱土及右旋布洛芬/酸改性蒙脱土复合物进行了结构表征，筛选出最佳酸处理浓度；采用透析法对右旋布洛芬/酸改性蒙脱土复合体系进行了体外释放实验。结果表明：经酸改性后蒙脱土的结构发生改变，当盐酸质量分数为15 %时，蒙脱土的比表面积达到最大值246 m2/g，比改性前提高了10.7倍。上载右旋布洛芬后，蒙脱土的载药量最大可达352.4 mg/g，比改性前提高了1.1倍，体外释放实验表明，右旋布洛芬/酸改性蒙脱土的累积释药质量分数受pH影响：在12h内，当pH为1.2和6.8时，其累积释药质量分数分别为18.6 %和89.3 %。 关键词：蒙脱土；酸处理；右旋布洛芬；体外释放 中图分类号： O611. 4 文献标识码：A Study on Preparation and in Vitro Release of Acid-montmorillonite Drug Delivery Sustained-release Systems LI Ting-ting, ZHAO Le-le, ZHANG Min, TIAN Qing-ping, ZHANG Shu-qiu (College of Pharmacy, Shanxi Medical University, Taiyuan 030001, Shanxi, China) Abstract：In order to?improve?the drug loading, the acid-montmorillonite as the carrier of S(+)-ibuprofen, and prepared S(+)-ibuprofen/acid-modified montmorillonite complexes, to explore the drug compounds release law in different pH values. The acid-montmorillonite was characterized by powder XRD, BET, SEM and so on. The effects of the pH of release media on in vitro release of the S(+)-ibuprofen were assessed by a dialysis method. The acid concentration of 15%, the specific surface area of montmorillonite is maximum 246 m2/g, increased by a factor of 10.7, and the drug-loading is 352.4 mg/g, increased by a factor of 1.1. In vitro release experiments showed that the cumulative release percentage amounts of the composite effect of pH, In the?artificial gastric juice (pH 1.2)?and in?the?artificial?intestinal?juice (pH 6.8)?, the in vitro cumulative amount of the composites were respectively, 18.6 % and 8 Key words: montmorillonite; acid-treatment; S(+)-ibuprofen; drug release Foundation item：Natural Science Foundation for Shanxi Province (No. 201601D202105) ; The Subject Clots Project Serving Pharmceutical Industrial Innovation of Shanxi Provence (2016); Foundation for PhD of Shanxi Medical 基金项目：山西省青年科技研究基金（201601D202105）；山西省服务制药产