肺泡上皮不典型腺瘤样增生要领.ppt

肺泡上皮不典型腺瘤样增生;肺泡上皮不典型腺瘤样增生(atypical adenomatous hyperplasia ,AAH),是指细胞沿着细支气管肺泡壁增生形成的，文献中该类病变出现的名称众多 ,如不典型肺泡(或肺泡不典型) 细胞增生、不典型细支气管肺泡细胞增生、细支气管肺泡上皮增生以及细支气管肺泡细胞腺瘤。 ;有的认为它仅是损伤后再生修复性增生,而另外一些学者认为它是损伤刺激后造成的，并由此导致细支气管肺泡癌(Bronchioloalveolar lung carcinoma ,BAC)的发生,因此认为AAH 是BAC 的癌前病变，甚至有学者认为是BAC 的早期癌。;AAH 细胞形态上类似于Clara 细胞或Ⅱ型肺泡细胞,呈立方形或矮柱状，肺泡壁因纤维化或淋巴细胞浸润而轻度增厚。;aHistological appearance of a low-grade (AAH) b high-grade AAH c early adenocarcinoma(AC) d overt AC;无典型和特征性性影像学表现，偶在体检中发现，主要依赖HRCT。 类圆形结节，直径大多6mm到15mm不等，一般不超过10mm，密度较均匀，形态较规则，边界较清楚。 ;computed tomography of chest shows a solitary nodular atypical adenomatous hyperplasia .the lesion appeared as around nodule with ground-glass opacity .note the smooth and distinct borders of the nodule .note aslo the absence of pleural.;histopathological findings :atypical epithelial cell proliferation along slightly thickened alveolar septa;one case(72-year-old female).chest CT shows a solitary nodule with a homogeneous ground-glass opacity .note the absence of convergence of pulmonary;细支气管肺泡癌 结核球 炎性假瘤 局部特发性肺间质纤维化 硬化性血管瘤 ;细支气管肺泡癌;谢谢