【毕业论文】哮喘滴丸治疗急性发作期轩哮喘的临床与实验研究.docVIP

山 东 中 医 药 大 学 研 究 生 毕 业 论 文 论 文 题 目：哮喘滴丸治疗急性发作期小儿哮喘的临床与实验研究 指 导 教 师： 学 生： 学科专业：中医儿科 入 学： 年9月1日 论文完成日期： 年9月10日 提 要 目的 本研究旨在从理论、临床及实验诸方面对哮喘滴丸治疗急性发作期小儿哮喘的疗效及机理进行系统观察与探讨，以寻求一种新的治疗药物。方法 临床研究将90例患儿随机分为2组，分别给予哮喘滴丸（观察组）及博利康尼加可迪美（对照组）口服 ，观察用药前后症状、体征以及实验室检查的变化。实验研究选择小鼠及豚鼠制作哮喘模型，观察哮喘滴丸灌胃后平喘、镇咳、祛痰、抗炎的作用并与博利康尼加可迪美阳性对照药物加以比较。结果 临床研究结果显示：观察组总有效率优于对照组；在平喘起效时间及主要症状体征、实验室检查方面也均优于对照组。实验研究结果显示：哮喘滴丸在平喘、镇咳、祛痰各个方面均近于或优于博利康尼加可迪美。结论 哮喘滴丸具有良好的平喘、镇咳、祛痰作用，对小儿哮喘急性发作具有良好的平喘效果，疗效优于博利康尼加可迪美。 关键词：哮喘滴丸 小儿哮喘 急性发作期 临床研究 实验研究 Clinical And Experiment Studies on Juvenile Bronchial Asthma Treated with Xiao Chuan Pill Specialty: Respiratory Disease, Pediatrics Medicine of TCM Author: Chen Lu Tutor: Professor Li Yan-ning Abstract Objective: To observe the clinical and experiment effect of Xiao Chuan Pill(XCP) and investigate the treatment mechanism to bronchial asthma and probe into the management method and prescription by the theory of the Traditional Chinese Medicine (TCM) and clinical and experiment studies. Methods: 90 children with asthma are randomly divided into 2 groups, treated with XCDW and Bricanyl and Composite Carbocisteine Bricanyl and Composite Carbocisteine respectively, observing change of the children’syndrome, physical sign and laboratory examination. Using mouse and guinea pig, TXB2, 6-Keto-PGF1αare examined in experiment study, comparing with blank group and Bricanyl and Composite Carbocisteine Bricanyl group. Results: Clinical study showed XCDW can alleviate syndrome and physical sign of the children and its total efficiency is batter than Bricanyl group. Experiment study showed the treatment of XCDW is similar to or batter than Bricanyl and Composite Carbocisteine Bricanyl in dissipating phlegm, relieving asthma and arresting cough. Conclusion: XCP can dissipate phlegm, relieve asthma, arrest cough and resist inflammation effectively. It is an effective medicine to juvenile bronchial asthma, batter than Bricanyl remarkable. Key words： Juvenile br