精神分裂症认知功能成套测验在首发精神分裂症患者中应用研究.docVIP

精神分裂症认知功能成套测验在首发精神分裂症患者中应用研究 　　[摘要] 目的 探讨首发和慢性精神分裂症患者的认知功能特点。 方法 选取2013年1月～2014年6月期间83例首发精神分裂症患者、77例慢性精神分裂症患者与75例健康志愿者，进行精神分裂症认知功能成套测验共识版（MCCB）测验，分析其认知剖面图模式及其认知功能损害特征。 结果 首发精神分裂症患者和慢性精神分裂症患者与健康对照组相比较，在MCCB中精神运动速度、注意、工作记忆、言语学习和记忆、视觉学习和记忆、推理和问题解决、社会认知等领域均存在受损（P0.05）。但首发精神分裂症患者与慢性精神分裂症患者在工作记忆和社会认知方面比较差异有统计学意义（P0.05）。 结论 首发精神分裂症患者在工作记忆和社会认知方面损害较慢性精神分裂症患者轻。精神分裂症患者不管是首发还是慢性较正常人群在认知功能方面均存在损害。 　　[关键词] 精神分裂症认知成套测验共识版；首发精神分裂症；认知；剖面图分析 　　[中图分类号] R749.3 [文献标识码] A [文章编号] 1673-9701（2015）21-0014-04 　　[Abstract] Objective To explore the characteristics of cognitive function in patients with the first-episode and chronic schizophrenia. Methods 83 cases of first-episode schizophrenia patients， 77 cases of chronic schizophrenia patients and 75 healthy volunteers from January 2013 to June 2014 were selected. MATRICS consensus cognitive battery （MCCB） test was conducted on them and their cognitive profile patterns and characteristics of cognitive function impairment were analyzed. Results Compared with the healthy control group， the first-episode schizophrenia patients and chronic schizophrenia patients got hurt in psychomotor speed， attention， working memory， verbal learning and memory， visual learning and memory， reasoning and problem solving ability， social cognition and other areas in the MCCB （P0.05）. There were differences in comparing working memory and social cognition of the first-episode schizophrenia patients and chronic schizophrenia patients （P0.05）. Conclusion The first-episode schizophrenia patients get less injury than chronic schizophrenia patients in the working memory and social cognition. Whether first-episode schizophrenia patients or chronic schizophrenia patients， they are impaired compared with the normal population in cognitive function. 　　[Key words] MATRICS consensus cognitive battery； First-episode schizophrenia； Cognitive； Profile analysis 　　近年来，精神分裂症的神经心理功能越来越受到国内外研究者的关注，有研究表明认知缺陷存在于精神分裂症患者中[1，2]，提出认知缺陷是精神分裂症的核心症状，认知缺陷应该成为精神分裂症的诊断标准之一[3]。由于精神分裂症是一个复杂