充血性心力衰竭的药物治疗教学课件.ppt

Use of β-blocker in CHFβ受体阻断药在慢性心衰中的应用 Heart failure is characterized by sympathetic hyperactivation, a neurohumoral state that reflects biological responses that can be both compensatory and maladaptive. 神经体液兴奋既是代偿又有适应不良 增加心肌耗氧 While many of sympathomimetics increased mortality in CHF patients, an unexpected mortality benefit was seen with the administration of β adrenergic blocking drugs. β adrenergic blockers reduce the heart work load and catecholamines myocardial toxicity, producing long-term benefits in patients with CHF.降低心肌工作负荷，减轻儿茶酚胺的心肌毒性，抑制肾素血管紧张素系统，改善心衰长期预后 Start β blocker at lose