超氧化物歧化酶及游离脂肪酸联合检测在胰岛素抵抗疾病中应用研究.docVIP

超氧化物歧化酶及游离脂肪酸联合检测在胰岛素抵抗疾病中应用研究 　　[摘要] 目的 探讨胰岛素抵抗与血清超氧化物歧化酶（SOD）及游离脂肪酸（FFA）的相关性。方法 随机选取该院2015年1月―2016年1月体检中心、门诊及入院人群符合胰岛素抵抗患者52例，非胰岛素抵抗组46例，对两组实验对象进行发放调查问卷并进行数据统计学分析，获得胰岛素抵抗组（实验组）与非抵抗组（对照组）SOD与FFA水平变化，了解SOD、FFA与胰岛素抵抗指数相关性。结果 实验组血清SOD测算含量约为（108.85±13.38）kU/L，显著低于对照组均值（P0.01），而实验组的血清FFA含量约为（0.67±0.28）mmol/L，明显高于对照组均值（P0.05）。同时FFA与SOD变化与胰岛素抵抗指数（HOMA-IR）呈现正相关（r=0.825 4，P0.01）和负相关（r=-0.632，P0.01）。结论 SOD及FFA联合检测在胰岛素抵抗疾病中的应用提供基础数据。SOD及FFA检测对监测胰岛素抵抗疾病病程发展、指导临床用药、预防和改善胰岛素抵抗疾病具有重要应用价值。 　　[关键词] 超氧化物歧化酶；游离脂肪酸；胰岛素抵抗 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-0742（2017）04（a）-0046-03 　　Research on Application of Combined Test of Superoxide Dispropor Tionation and Free Fatty Acid in the Insulin Resistance Diseases 　　LIN Yu-ting， MA Yun-hua， CAO Fu-jun 　　Department of Clinical Laboratory， Yantai Beihai Hospital， Yantai， Shandong Province， 264000 China 　　[Abstract] Objective To study the correlation between the insulin resistance and serum superoxide dispropor tionation and free fatty acid. Methods Random selection 52 cases of patients with insulin resistance in the physical examination center and clinic in our hospital from January 2015 to January 2016 were selected and the two groups were issued to the questionnaires for statistical analysis， and the changes of SOD and FFA levels of the two groups were obtained and the correlation between SOD， FFA and insulin resistance index were known. Results The serum SOD measurement constant in the experimental group was（108.85±13.38）kU/L， which was obviously lower than that in the control group（P0.01）， but the serum FFA constant in the experimental group was about（0.67±0.28）mmol/L， which was obviously higher than that in the control group（P0.05）， at the same time， the changes of FFA and SOD showed a positive correlation with the HOMA-IR（r=0.825 4，P0.01） and showed a negative correlation with the HOMA-IR（r=-0.632， P0.01）. Conclusion The combined test of SOD and FFA provides the basic data for the insulin resistance diseases， and the SOD and