基因的变异单核苷酸多态性（SNP）-汕头大学医学院医学细胞生物学.pptVIP

Gene Variationssingle nucleotides polymorphismcopy number variation 刘戈飞 汕头大学医学院遗传学与细胞生物学教研室 gfliu@ 075488900497Genetic Markers Morphological markers Cytological markers Biochemical and physiological markers Molecular markers SNP Effects SNPs in genes In coding regions (possible protein structure changes) ? Synonymous substitutions (同义) ? Missense substitutions (错义) ? Nonsense substitutions (终止) In coding and non-coding regions ? Change of gene expression (by diverse binding various factors) Yield Timing Alternative splicing SNPs in regulatory regions Chan