莪术油联合丝裂霉素化疗栓塞晚期膀胱癌疗效临床研究.docVIP

莪术油联合丝裂霉素化疗栓塞晚期膀胱癌疗效的临床研究 摘要 目的：对中药莪术油在膀胱动脉灌注化疗栓塞治疗晚期膀胱癌的临床疗效进行观察研究。研究方法：随机将不能手术切除的晚期膀胱患者60例分为2组，两组均给予膀胱动脉灌注化疗栓塞治疗，治疗组在与对照组等同治疗的基础上加用莪术油栓塞膀胱动脉。分别比较两组治疗后肿瘤体积缩小率；患者生活质量；比较两组治疗后血小板、白细胞、血红蛋白、谷丙转氨酶、谷草转氨酶、血清总胆红素水平，进而探讨其疗效。 结果：在莪术油联合丝裂霉素化疗栓塞膀胱动脉的治疗过程中，采用碘化油+丝裂霉素混合乳剂栓塞双侧膀胱动脉的对照组对肿瘤的抑制效果为46.7%，然而在碘化油+丝裂霉素+莪术油的观察组的有效率达到了63.3%，其中观察组治疗之后的肿瘤大小是，对照组的89.03% ，在接受莪术油联合丝裂霉素化疗的观察组生活质量的评分在30分以上达到较好状态的有29人占中治疗人数的96.7%，对照组在30分以上的人只有83.3%，谷丙转氨酶、谷草转氨酶及血清胆红素都得到了明显的降低，由于化疗引起的血小板、白细胞、血红蛋白的降低得到了较好的保护作用。 结论：莪术油联合丝裂霉素对膀胱癌肿瘤细胞的生长具有明显的抑制增效作用,同时莪术油对肝功能的损伤修复及血细胞的损伤保护具有明显的作用，在莪术油联用丝裂霉素的治疗过程中，莪术油发挥改善病人生活质量和良好恢复的功效。 关键词：莪术油；联合丝裂霉素；栓塞化疗；膀胱癌晚期；临床研究 Abstract Objective: To observe the traditional Chinese medicine Curcuma oil in clinical efficacy studies of bladder arterial chemoembolization treatment of advanced bladder cancer. Methods: A total of unresectable advanced bladder 60 patients were divided into two groups, two groups were given bladder arterial chemoembolization therapy, the treatment group Curcuma oil bladder artery embolization in the control group on the basis of equal treatment. After treatment were compared tumor volume reduction rate; the quality of life of patients; after treatment were compared platelets, white blood cells, hemoglobin, alanine aminotransferase, aspartate aminotransferase, serum total bilirubin level, and then explore its efficacy. Results: During treatment with mitomycin Curcuma oil artery chemoembolization bladder, using iodized oil emulsion + mitomycin mixed arterial embolization of bilateral bladder control group of tumor suppression effect was 46.7%, whereas in iodine oils + mitomycin + Curcuma oil observation group efficiency reached 63.3%, of which the tumor size was observed after treatment group was 89.03% in the control group, receiving Curcuma oil mitomycin chemotherapy in the observation group to achieve a better quality of life scores 30 points or more in the state, 29 people accounted for 96.7% of the number of patients in the control group were more than