胃癌血清肿瘤标志物的研究进展-兰州大学学报.PDF

第41 卷 第3 期 兰州大学学报（医学版） Vol.41 No.3 2015 年6 月 Journal of Lanzhou University （Medical Sciences ） Jun. 2015 文章编号：1000-2812 (2015) 03-0075-06 胃癌血清肿瘤标志物的研究进展 1,2 1,2 1,2 1,2 姬 瑞 ，周圣辉 ，王玉平 ，周永宁 1. 兰州大学第一医院 消化科，甘肃 兰州 730000 2. 兰州大学 甘肃省胃肠病重点实验室，甘肃 兰州 730000 摘要：胃癌的发病率高、死亡率高，严重威胁人类健康，但其早期诊断率低。胃癌早期筛查和诊断主要依靠有创性的 检查，如胃镜和活检，费用比较高，可行性较差。血清肿瘤标志物以其简便、快捷、无痛苦等优点，成为胃癌患者的 理想检查指标。本文主要就近期相关肿瘤标志物的研究以及其对胃癌的协助诊断、预后评估做一综述。 关键词：胃癌；血清；肿瘤标志物 中图分类号：R735.2 文献标识码：A doi ：10.13885/j.issn. 1000-2812.2015.03.015 Research progress of serum tumor markers in gastric cancer Ji Rui1,2 , Zhou Sheng-hui1,2 , Wang Yu-ping1,2 , Zhou Yong-ning1,2 1. Department of Gastroenteropathy, First Hospital of Lanzhou University, Lanzhou 730000, China 2. Key Laboratory for Gastrointestinal Diseases of Gansu Province, Lanzhou university, Lanzhou 730000, China Abstract ：：Gastric cancer is one of the most common cancers in the world presently. In recent years, gastric cancer seriously threat human health with its high incidence and mortality. However, the rate of its early diagnosis is low. Currently, the diagnosis of gastric cancer mainly depends on invasive examination such as gastroscopy and biopsy with relatively higer cost and poor feasibility. Serum tumor markers have became an important and ideal examination index of gastric cancer recently because of their simple, quick, painless and other advantages. In this article, we aimed to summarize recent studied tumor markers and its assistance for the early diagnosis and prognostic evaluation of gastric cancer. In the end, we look forward the follow- up studies on gastric cancer serum tumor markers. Key words: gastric cancer; serum; tumor markers 全球恶性肿瘤死亡率中胃癌居第2 位，每年 和临床实践中，检测血清肿瘤标志物诊断胃癌， [1] 死亡人数约70 万 。胃癌患者早期多无症状或