周细胞和微血管疾病及中医药研究进展.docVIP

周细胞和微血管疾病及中医药研究进展 　　[摘要]周细胞是广泛分布于全身微血管壁的结构细胞，和内皮细胞一起构成微血管和组织间隙的屏障。周细胞通过细胞连接或旁分泌信号与微血管内皮细胞对话，在调控微循环血流量、微血管通透性及血管新生等方面发挥重要作用。多种疾病的微血管病变伴随周细胞结构和功能异常，周细胞的调控成为研究热点。中医学认为微血管病变属于络脉受损，气血瘀滞于络脉导致的脏腑功能异常。中医药干预微血管病变周细胞改变取得了一些进展，如益气活血类中药对于糖尿病视网膜病变微血管周细胞具有较好的改善作用。但是，中医药在微血管病变周细胞研究中也存在着研究领域局限、研究技术和方法不精确及机制阐述深度不足等问题。该文将从周细胞的生物学特征、周细胞与微血管病变及中医药研究进展展开综述，旨为微血管病变周细胞研究及其中医药防治研究提供参考。 　　[关键词]周细胞；微血管疾病；中医药 　　Recent advances on pericytes in microvascular dysfunction and 　　traditional Chinese medicine prevention 　　LI Lei1，2， LIU Jianxun1，2*， GUO Hao1，2， REN Jianxun1，2 　　（1 Institute of Basic Medical Sciences of Xiyuan Hospital， China Academy of Chinese Medical Sciences， Beijing 100091， China； 　　2. Beijing Key Laboratory of Chinese Materia Pharmacology， Beijing 100091， China） 　　[Abstract]Pericytesis a kind of widespread vascular mural cells embedded within the vascular basement membrane of blood microvessels， constituting the barrier of capillaries and tissue spaces together with endothelial cells Pericytes communicate with microvascular endothelial cells through cell connections or paracrine signals， playing an important role in important physiological processes such as blood flow， vascular permeability and vascular formation Pericytes dysfunction may participate in some microvascular dysfunction， and also mediate pathological repair process， therefore pericytes attracted more and more attention Traditional Chinese medicine suggests that microvascular dysfunction belongs to the collaterals disease； Qi stagnation and blood stasis in collaterals result in function imbalance of internal organs Traditional Chinese medicine （TCM） has shown effects on pericytes in microvascular dysfunction， for example qi reinforcing bloodcirculation activating medicines can reduce the damage of retinal pericytes in diabetic retinopathy However， there are some limitations of research fields， inaccuracy of research techniques and methods， and lack of mechanism elaboration depth in the study of microvascula