口服地塞米松治疗婴幼儿头颈部增生期血管瘤临床的研究.docVIP

口服地塞米松治疗婴幼儿头颈部增生期血管瘤临床的研究 　　【摘要】 目的 探讨口服地塞米松治疗婴幼儿头颈部增生期血管瘤的临床效果及最佳剂量。方法 婴幼儿头颈部增生期血管瘤患者90例,随机分为实验组(口服地塞米松治疗组)35例;对照组(平阳霉素注射治疗组30例,随诊观察组25例)55例,随诊3~20个月。结果 口服地塞米松治疗组总有效率为88.6%(31/35),平阳霉素注射治疗组总有效率为90.0%(27/30),随诊观察组总有效率为64.0%(16/25),口服地塞米松治疗组和平阳霉素注射治疗组疗效相当,均优于随诊观察组(P0.05),各组均未出现严重并发症。结论 口服地塞米松治疗婴幼儿头颈部增生期血管瘤方法简单、疗效可靠、不良反应小,值得临床推广应用。 　　【关键词】地塞米松;血管瘤;增生期;头颈部 　　 　　Clinical research of oral dexamethasone therapy to treat infancy proliferative hemangiomas of head and neck region 　　 　　ZHUO Jian-qiang,LAI Chun-shan,LI Xiao-jing,et al.Department of Otolaryngology,Peng pai Memorial Hospital,Shanwei 516400,China 　　 　　【Abstract】 Objective To study the clinical effects and optimal doses of oral dexamethasone therapy to treat infancy proliferative hemangiomas of head and neck region.Methods 90 infants with head-neck proliferative hemangiomas were divided into 3 groups randomly.35 cases were orally treatment with optimal dose of dexamethasone and 30 cases were treatment with optimal dose of pingyangmycin injection.Both dose were based on the patients’age and size of the lesion.The other 25 infants were fellow-up without any treatment.All patients were evaluated clinical effects after follow-up 3 months to 20 months.Results The total effective rate in group of orally treatment with dexamethasone was 88.6% and was equivalent to the especially for the treatment of cavernous hemangioma of the most satisfied with the pingyangmycin injection group with 90.0%,and both were superior to the fellow-up group64.0%.All patients were follow-up without severe complications.Conclusion Oral dexamethasone therapy to treat infancy proliferative hemangiomas of head and neck region with simple and easy method,high efficacy and mild side effects,is worth to utilize in clinical treatment. 　　【Key words】 Dexamethasone; Hemangiomas; Proliferative phase; Head and neck region 　　 　　婴幼儿血管瘤(infantile hemangioma)是由血管组织构成的先天性良性肿瘤,其发病率高达10%,是婴幼儿期最常见的良性肿瘤,可发生于皮肤、皮下组织、肌、骨及脑、肝、心等组织脏器,女性较男性多见,其确切发病机制仍不清楚[1]。